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Journal of Diabetes Research
Volume 2015, Article ID 150176, 10 pages
Review Article

Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1

Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan

Received 15 September 2014; Revised 27 January 2015; Accepted 3 February 2015

Academic Editor: Joseph Fomusi Ndisang

Copyright © 2015 Samreen Riaz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the present research work, the levels of protein biomarkers specific to diabetes mellitus type 2 in the Pakistani population using proteomic technology have been identified and characterized and effect of high dose thiamine has been seen on the levels of these marker proteins. Diabetic patients and normal healthy controls were recruited from the Sheikh Zayed Hospital, Lahore, Pakistan. Total biochemical assays and proteins were estimated by modern proteomic techniques. Some proteins were up- and downregulated in diabetic samples as compared to control and decreased after thiamine therapy, while other protein markers did not show a significant change after the thiamine therapy. The effect of high dose thiamine on the levels of these identified protein biomarkers in the human urine has also been observed. Assessment of the levels of these biomarkers will be helpful in not only early diagnosis but also prognosis of diabetes mellitus type 2.