Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2016, Article ID 1527852, 3 pages
http://dx.doi.org/10.1155/2016/1527852
Editorial

Role of Tissue and Systemic Hypoxia in Obesity and Type 2 Diabetes

1Pauley Heart Center, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23298-0204, USA
2Department of Sports Medicine, Chengdu Sport University, Chengdu 610041, China
3Delta Sleep Research Unit, Exercise Health and Performance Group, Faculty of Health Sciences, The University of Sydney, Sydney, NSW 2141, Australia
4Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA

Received 19 May 2016; Accepted 19 May 2016

Copyright © 2016 Lei Xi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. J. Reichmuth, D. Austin, J. B. Skatrud, and T. Young, “Association of sleep apnea and type II diabetes: A Population-Based Study,” American Journal of Respiratory and Critical Care Medicine, vol. 172, no. 12, pp. 1590–1595, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Ye, Z. Gao, J. Yin, and Q. He, “Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice,” American Journal of Physiology—Endocrinology and Metabolism, vol. 293, no. 4, pp. E1118–E1128, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Ye, “Emerging role of adipose tissue hypoxia in obesity and insulin resistance,” International Journal of Obesity, vol. 33, no. 1, pp. 54–66, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. Q. He, Z. Gao, J. Yin, J. Zhang, Z. Yun, and J. Ye, “Regulation of HIF-1α activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia,” American Journal of Physiology—Endocrinology and Metabolism, vol. 300, no. 5, pp. E877–E885, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Yin, Z. Gao, Q. He, D. Zhou, Z. Guo, and J. Ye, “Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue,” American Journal of Physiology—Endocrinology and Metabolism, vol. 296, no. 2, pp. E333–E342, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Muraki, T. Tanigawa, K. Yamagishi et al., “Nocturnal intermittent hypoxia and the development of type 2 diabetes: The Circulatory Risk in Communities Study (CIRCS),” Diabetologia, vol. 53, no. 3, pp. 481–488, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. C. E. Korcarz, J. H. Stein, P. E. Peppard, T. B. Young, J. H. Barnet, and F. J. Nieto, “Combined effects of sleep disordered breathing and metabolic syndrome on endothelial function: the wisconsin sleep cohort study,” Sleep, vol. 37, no. 10, pp. 1707–1713, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. O. Bouhidel, S. Pons, R. Souktani, R. Zini, A. Berdeaux, and B. Ghaleh, “Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 295, no. 4, pp. H1580–H1586, 2008. View at Publisher · View at Google Scholar
  9. K. Przyklenk, M. Maynard, D. L. Greiner, and P. Whittaker, “Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes,” Antioxidants and Redox Signaling, vol. 14, no. 5, pp. 781–790, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. S.-G. Zhu, L. Xi, and R. C. Kukreja, “Type 2 diabetic obese db/db mice are refractory to myocardial ischaemic post-conditioning in vivo: potential role for Hsp20, F1-ATPase δ and Echs1,” Journal of Cellular and Molecular Medicine, vol. 16, no. 4, pp. 950–958, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Sarjeant and J. M. Stephens, “Adipogenesis,” Cold Spring Harbor Perspectives in Biology, vol. 4, no. 9, article a008417, 2012. View at Google Scholar · View at Scopus
  12. B. Viollet, B. Guigas, N. S. Garcia, J. Leclerc, M. Foretz, and F. Andreelli, “Cellular and molecular mechanisms of metformin: an overview,” Clinical Science, vol. 122, no. 6, pp. 253–270, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Sommer, A. Dietrich, R. T. Schermuly et al., “Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms,” European Respiratory Journal, vol. 32, no. 6, pp. 1639–1651, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Louis and N. M. Punjabi, “Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers,” Journal of Applied Physiology, vol. 106, no. 5, pp. 1538–1544, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Urdampilleta, P. González-Muniesa, M. P. Portillo, and J. A. Martínez, “Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity,” Journal of Physiology and Biochemistry, vol. 68, no. 2, pp. 289–304, 2012. View at Publisher · View at Google Scholar · View at Scopus