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Journal of Diabetes Research
Volume 2016 (2016), Article ID 1587594, 7 pages
http://dx.doi.org/10.1155/2016/1587594
Research Article

Free Fatty Acids Activate Renin-Angiotensin System in 3T3-L1 Adipocytes through Nuclear Factor-kappa B Pathway

1Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
2Department of Geratology, The Affiliated Hospital of Guangdong Medical College, Guangdong Medical College, Zhanjiang, Guangdong, China
3Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical College, Dongguan, Guangdong, China
4Second Clinical School of Medicine, Southern Medical University, Guangzhou, China
5Nephrology Center of Integrated Traditional Chinese and Western Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China

Received 27 August 2015; Accepted 20 October 2015

Academic Editor: Xingxing Kong

Copyright © 2016 Jia Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Tomono, M. Iwai, S. Inaba, M. Mogi, and M. Horiuchi, “Blockade of AT1 receptor improves adipocyte differentiation in atherosclerotic and diabetic models,” American Journal of Hypertension, vol. 21, no. 2, pp. 206–212, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Jing, M. Mogi, and M. Horiuchi, “Role of renin-angiotensin-aldosterone system in adipose tissue dysfunction,” Molecular and Cellular Endocrinology, vol. 378, no. 1-2, pp. 23–28, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. W. A. Banks, L. M. Willoughby, D. R. Thomas, and J. E. Morley, “Insulin resistance syndrome in the elderly: assessment of functional, biochemical, metabolic, and inflammatory status,” Diabetes Care, vol. 30, no. 9, pp. 2369–2373, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Putnam, R. Shoemaker, F. Yiannikouris, and L. A. Cassis, “The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 302, no. 6, pp. H1219–H1230, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Suganami, M. Tanaka, and Y. Ogawa, “Adipose tissue inflammation and ectopic lipid accumulation,” Endocrine Journal, vol. 59, no. 10, pp. 849–857, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Giacchetti, L. A. Sechi, C. A. Griffin, B. R. Don, F. Mantero, and M. Schambelan, “The tissue renin-angiotensin system in rats with fructose-induced hypertension: overexpression of type 1 angiotensin II receptor in adipose tissue,” Journal of Hypertension, vol. 18, no. 6, pp. 695–702, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Gorzelniak, S. Engeli, J. Janke, F. C. Luft, and A. M. Sharma, “Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension,” Journal of Hypertension, vol. 20, no. 5, pp. 965–973, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. I. Hainault, G. Nebout, S. Turban, B. Ardouin, P. Ferré, and A. Quignard-Boulangé, “Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat,” The American Journal of Physiology—Endocrinology and Metabolism, vol. 282, no. 1, pp. E59–E66, 2002. View at Google Scholar · View at Scopus
  9. N. S. Kalupahana, F. Massiera, A. Quignard-Boulange et al., “Overproduction of angiotensinogen from adipose tissue induces adipose inflammation, glucose intolerance, and insulin resistance,” Obesity, vol. 20, no. 1, pp. 48–56, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. N. S. Kalupahana and N. Moustaid-Moussa, “The adipose tissue renin-angiotensin system and metabolic disorders: a review of molecular mechanisms,” Critical Reviews in Biochemistry and Molecular Biology, vol. 47, no. 4, pp. 379–390, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Azekoshi, T. Yasu, S. Watanabe et al., “Free fatty acid causes leukocyte activation and resultant endothelial dysfunction through enhanced angiotensin II production in mononuclear and polymorphonuclear cells,” Hypertension, vol. 56, no. 1, pp. 136–142, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Watanabe, T. Tagawa, K. Yamakawa, M. Shimabukuro, and S. Ueda, “Inhibition of the renin-angiotensin system prevents free fatty acid-induced acute endothelial dysfunction in humans,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 11, pp. 2376–2380, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Boden, “Free fatty acids (FFA), a link between obesity and insulin resistance,” Frontiers in Bioscience, vol. 3, pp. d169–d175, 1998. View at Google Scholar · View at Scopus
  14. D. Pal, S. Dasgupta, R. Kundu et al., “Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance,” Nature Medicine, vol. 18, no. 8, pp. 1279–1285, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Putnam, F. Batifoulier, K. G. Bharadwaj et al., “RAS regulate adipocyte differentiation through Ang II and the adipocyte AT1R in mice,” Endocrinology, vol. 153, no. 10, pp. 4677–4686, 2012. View at Google Scholar
  16. H. Shi, M. V. Kokoeva, K. Inouye, I. Tzameli, H. Yin, and J. S. Flier, “TLR4 links innate immunity and fatty acid-induced insulin resistance,” The Journal of Clinical Investigation, vol. 116, no. 11, pp. 3015–3025, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Shirai, H. Yoshiji, R. Noguchi et al., “Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis,” Journal of Gastroenterology and Hepatology, vol. 28, no. 4, pp. 723–730, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Hua, Q. Peng, and H. Y. Wang, “Effect of activating toll like receptor 4 on AGT and AT1R in myocardiocytes,” Chinese Journal of Hypertension, vol. 16, no. 4, pp. 336–339, 2008. View at Google Scholar
  19. V. Serazin, M.-N. Dieudonné, M. Morot, P. De Mazancourt, and Y. Giudicelli, “cAMP-positive regulation of angiotensinogen gene expression and protein secretion in rat adipose tissue,” The American Journal of Physiology—Endocrinology and Metabolism, vol. 286, no. 3, pp. E434–E438, 2004. View at Google Scholar · View at Scopus
  20. T. Skurk, V. van Harmelen, and H. Hauner, “Angiotensin II stimulates the release of interleukin-6 and interleukin-8 from cultured human adipocytes by activation of NF-κB,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 7, pp. 1199–1203, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Jinhua, S. Jia, and C. Dehong, “Effect of activating toll like receptor 4 on renin-angiotensin system in 3T3-L1 adipose cells,” Journal of Southern Medical University, vol. 34, no. 6, pp. 787–791, 2014. View at Google Scholar
  22. A. S. Baldwin Jr., “The NF-κB and IκB proteins: new discoveries and insights,” Annual Review of Immunology, vol. 14, no. 1, pp. 649–681, 1996. View at Publisher · View at Google Scholar
  23. K. Miyata, R. Satou, W. Shao et al., “ROCK/NF-kappaB axis-dependent augmentation of angiotensinogen by angiotensin ii in primary-cultured preglomerular vascular smooth muscle cells,” The American Journal of Physiology—Renal Physiology, vol. 306, no. 6, pp. F608–F618, 2014. View at Publisher · View at Google Scholar · View at Scopus