Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2016, Article ID 2481659, 7 pages
http://dx.doi.org/10.1155/2016/2481659
Review Article

The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension

1Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298, USA
2Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298, USA
3Division of Endocrinology, Virginia Commonwealth University Health System, Richmond, VA 23298, USA

Received 17 February 2016; Accepted 11 May 2016

Academic Editor: Chin-Moi Chow

Copyright © 2016 Daniel Grinnan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pulmonary hypertension is a progressive disorder which often leads to right ventricular failure and death. While the existing classification system for pulmonary hypertension does not account for the impact of diabetes mellitus, evidence is emerging that suggests that diabetes is associated with pulmonary hypertension and that diabetes modifies the course of pulmonary hypertension. There is also growing radiographic, hemodynamic, biochemical, and pathologic data supporting an association between diabetes and pulmonary hypertension. More robust epidemiologic studies are needed to confirm an association between diabetes and pulmonary hypertension and to show that diabetes is a disease modifier in pulmonary hypertension. In addition, evaluating the effects of glucose control in animals with pulmonary hypertension and diabetes (as well as in humans) is warranted.