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Journal of Diabetes Research
Volume 2016, Article ID 3271293, 5 pages
Research Article

Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus

1Section of Endocrinology, Metabolism and Diabetes, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USA
2Division of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, The Clinical Research Center, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
3Department of Pediatrics, University of Kentucky, Lexington, KY 40506, USA
4The Research Institute, Nationwide Children’s Hospital, Columbus, OH 43205, USA

Received 1 June 2015; Accepted 14 July 2015

Academic Editor: Shuangxi Wang

Copyright © 2016 Rachel-Marie Cazeau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background/Objectives. Endothelial dysfunction due to hyperglycemia-induced oxidative damage is an important predictor of future cardiovascular risk in patients with type 1 diabetes mellitus (T1DM) and is present in adolescent T1DM. We hypothesized that combined treatment with the antioxidant vitamins C and E might improve endothelial function (EF) and other biochemical risk factors in adolescents with T1DM. Subjects/Methods. Open-label antioxidant supplementation was given for six weeks with endpoint measurements collected at baseline and study completion. Endpoints measured included EF and plasma measurements of biochemical endothelial risk. Results. Two males and 7 females were studied. Mean age was 12.9 ± 0.9 yrs; mean T1DM duration was 5.5 ± 2.5 yrs; mean BMI was 22.1 ± 3.8 kg/m2; and mean hemoglobin A1c was 9.3 ± 1.1%. No differences were found for EF, high sensitivity CRP, total antioxidant capacity, adiponectin, or endothelial progenitor cells (EPCs) between before and after combined vitamin C and E therapy. Conclusions. Our negative study results do not support previous findings of decreased oxidative damage, improved endothelial function, and increased vascular repair capacity with antioxidant therapy. Longer term studies may be needed to determine the effects, if any, of combined antioxidant therapy on EPCs, EF, and markers of micro- and macrovascular complications in T1DM.