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Journal of Diabetes Research
Volume 2017, Article ID 3797802, 14 pages
Review Article

Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy

1Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin 130041, China
2Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin 130041, China
3Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin 130031, China

Correspondence should be addressed to Bing Du; moc.621@anivadbd and Ping Luo; moc.361@nejgnipoul

Received 19 December 2016; Revised 9 February 2017; Accepted 13 March 2017; Published 23 April 2017

Academic Editor: Wei J. Liu

Copyright © 2017 Wenpeng Cui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, exploring new strategies for the treatment of this disease is urgently needed. Oxidative stress takes part in the initiation and development of DN. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in the cellular response to oxidative stress. Thus, activation of Nrf2 seems to be a new choice for the treatment of DN. In current review, we discussed and summarized the therapeutic effects of Nrf2 activation on DN from both basic and clinical studies.