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Journal of Diabetes Research
Volume 2017, Article ID 6483572, 15 pages
Research Article

PGC1α Activators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control

1Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
2Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Republic of Korea

Correspondence should be addressed to Dong Ho Yang; and Sang Ho Lee;

Received 19 October 2016; Accepted 30 November 2016; Published 20 March 2017

Academic Editor: Jochen Reiser

Copyright © 2017 So-Young Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

We performed flow cytometry analysis using MitoSox showing reduced level of mitochondrial ROS production by treatment of PGC1a activators under high glucose condition in HKC8 cells (Supplementary Figure 1). Supplementary Figure 2 provides high magnified images of kidneys (PAS and Masson’s trichorme staining) from normal control, diabetic control, diabetes + metformin and diabetic + AICAR groups. Supplementary Figure 3 showed the results of western blot analysis suggesting restoration of phosphorylated and total PGC1a expression by treatment of AICAR or metformin in diabetic kidneys.

  1. Supplementary Material