Journal of Diabetes Research

Compensatory Mechanisms of Pancreatic Beta Cells: Insights into the Therapeutic Perspectives for Diabetes


Publishing date
04 Jul 2014
Status
Published
Submission deadline
14 Feb 2014

1Lille 2 University, EGID FR 3508, Faculty of Medicine, Research Department, 1 place de Verdun, 59045 Lille, France

2Department of Fundamental Neurosciences Faculty of Biology and Medicine University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland

3Institute of Functional Genomic INSERM 661, CNRS 5203, Montpellier 1 and 2 Universities, Montpellier, France


Compensatory Mechanisms of Pancreatic Beta Cells: Insights into the Therapeutic Perspectives for Diabetes

Description

Diabetes prevalence has risen dramatically during the last 20 years in parallel to the pandemic of obesity. The disease develops when insulin production is insufficient to compensate for the increased insulin requirements elicited by insulin resistance. Defective circulating insulin levels are the consequence of reduced beta cells number and decreased secretory capacity of the remaining beta cells.

Despite being exposed to environmental risk factors including excess of food and sedentary lifestyles, many obese and insulin resistant people do not suffer from diabetes. This situation is thought to result from the capacity of beta cells to resist against diabetogenic factors and to adapt their mass and function in order to produce enough insulin to compensate for the increased demand from target tissues. Such plastic ability is a physiological process that occurs in efficiently from birth to early childhood periods and during pregnancy. Protection and adaptation of beta cells has been shown to result from humoral mediators, which activate several intracellular adaptive pathways. So far, the interplay between these signaling cascades remains poorly understood. An integrative understanding of the events underlying beta cell adaptation will pave the way for the development of innovative strategies and new therapeutic approaches aiming to preserve beta cell activity in diabetes. We invite authors to submit original research and review papers investigating the contribution and the mode of action of a broad range of molecules including nutrients, hormones and plasma signals involved in beta cell adaptation. Potential topics include, but are not limited to:

  • Signals from gestational and obesogenic environment fostering beta cell mass and function
  • Role of microRNAs and long noncoding RNA in beta cells compensation and protection
  • Entero-humoral signals eliciting beta cell function in metabolic surgery
  • Identification of signaling and intracellular key targets that can be triggered for preserving beta cell function in diabetes

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/jdr/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jdr/comp/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 217387
  • - Editorial

Compensatory Mechanisms of Pancreatic Beta Cells: Insights into the Therapeutic Perspectives for Diabetes

Romano Regazzi | Stephane Dalle | Amar Abderrahmani
  • Special Issue
  • - Volume 2014
  • - Article ID 814854
  • - Research Article

JNK3 Is Required for the Cytoprotective Effect of Exendin 4

Hélène Ezanno | Valérie Pawlowski | ... | Amar Abderrahmani
  • Special Issue
  • - Volume 2014
  • - Article ID 795171
  • - Review Article

Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes

Nabil Rabhi | Elisabet Salas | ... | Jean-Sébastien Annicotte
  • Special Issue
  • - Volume 2014
  • - Article ID 618652
  • - Review Article

Role of MicroRNAs in Islet Beta-Cell Compensation and Failure during Diabetes

Valérie Plaisance | Gérard Waeber | ... | Amar Abderrahmani
  • Special Issue
  • - Volume 2014
  • - Article ID 294017
  • - Clinical Study

Comparison of Metformin and Repaglinide Monotherapy in the Treatment of New Onset Type 2 Diabetes Mellitus in China

J. Ma | L. Y. Liu | ... | W. Liu
  • Special Issue
  • - Volume 2014
  • - Article ID 768024
  • - Review Article

Decompensation of β-Cells in Diabetes: When Pancreatic β-Cells Are on ICE(R)

Roberto Salvi | Amar Abderrahmani
  • Special Issue
  • - Volume 2014
  • - Article ID 873679
  • - Review Article

Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions

Elisabet Salas | Nabil Rabhi | ... | Jean-Sébastien Annicotte
Journal of Diabetes Research
 Journal metrics
Acceptance rate34%
Submission to final decision85 days
Acceptance to publication27 days
CiteScore3.020
Impact Factor3.040
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