Research Article
Evaluation of Modified Date Palm (Phoenix dactylifera L.) Mucilage as a Potential Pharmaceutical Excipient
Table 2
Effect of temperature on solubility and swelling index of HPMC, paracetamol, and date palm mucilage granules.
| Sr. No. | Property | T (°C) | Crude mucilage | Purified mucilage | Acidic hydrolyzed mucilage | Basic hydrolyzed mucilage | Amylase hydrolyzed mucilage | Cellulase hydrolyzed mucilage | Poly acrylamide grafted mucilage | ZnO-NPs mucilage | CuO-NPs mucilage | Ag-NPs mucilage | Au-NPs mucilage | HPMC | Paracetamol |
| 1 | Solubility (%) | 25 | 5.2 ± 0.019 | 5.92 ± 0.024 | 4.7 ± 0.03 | 5.5 ± 0.01 | 6.1 ± 0.01 | 6.5 ± 0.02 | 4.3 ± 0.1 | 0.07 ± 0.003 | 0.5 ± 0.001 | 0.045 ± 0.001 | 0.03 ± 0.0019 | 9.6 ± 0.09 | 12.5 ± 0.13 | 35 | 5.8 ± 0.02 | 6.8 ± 0.031 | 5.1 ± 0.01 | 5.9 ± 0.13 | 6.3 ± 0.08 | 6.9 ± 0.02 | 4.4 ± 0.08 | 0.1 ± 0.005 | 0.55 ± 0.003 | 0.051 ± 0.001 | 0.033 ± 0.001 | 11.5 ± 0.1 | 13.1 ± 0.11 | 50 | 7.4 ± 0.015 | 8.2 ± 0.11 | 5.7 ± 0.01 | 6.1 ± 0.014 | 7.1 ± 0.02 | 7.4 ± 0.1 | 4.9 ± 0.12 | 0.12 ± 0.001 | 0..59 ± 0.001 | 0.071 ± 0.003 | 0.041 ± 0.002 | 15.3 ± 0.13 | 13.9 ± 0.1 | 65 | 7.9 ± 0.05 | 9.1 ± 0.01 | 6.4 ± 0.013 | 6.5 ± 0.011 | 7.5 ± 0.14 | 7.7 ± 0.09 | 5.6 ± 0.016 | 0.18 ± 0.001 | 0.65 ± 0.002 | 0.085 ± 0.001 | 0.055 ± 0.001 | 15.8 ± 0.11 | 14.4 ± 0.1 | 80 | 8.8 ± 0.05 | 11.3 ± 0.05 | 7.6 ± 0.06 | 9.5 ± 0.1 | 8.5 ± 0.11 | 8.2 ± 0.05 | 6.2 ± 0.06 | 0.26 ± 0.008 | 0.85 ± 0.001 | 0.15 ± 0.009 | 0.063 ± 0.0013 | 17.3 ± 0.1 | 16.9 ± 0.08 |
| 2 | Swelling index | 25 | 1.9 ± 0.022 | 1.99 ± 0.037 | 1.65 ± 0.04 | 1.85 ± 0.016 | 2.13 ± 0.01 | 2.2 ± 0.68 | 1.68 ± 0.13 | 0.58 ± 0.008 | 0.51 ± 0.006 | 0.43 ± 0.001 | 0.31 ± 0.003 | 3.9 ± 0.15 | 4.45 ± 0.17 | 35 | 1.9 ± 0.017 | 2.3 ± 0.042 | 1.96 ± 0.09 | 2.11 ± 0.019 | 2.45 ± 0.05 | 2.7 ± 0.59 | 1.77 ± 0.07 | 0.67 ± 0.002 | 0.54 ± 0.001 | 0.49 ± 0.004 | 0.35 ± 0.002 | 4.5 ± 0.28 | 5.74 ± 0.14 | 50 | 2.1 ± 0.009 | 2.5 ± 0.018 | 2.01 ± 0.18 | 2.15 ± 0.008 | 2.73 ± 0.05 | 2.8 ± 0.41 | 1.81 ± 0.18 | 0.7 ± 0.009 | 0.58 ± 0.009 | 0.53 ± 0.004 | 0.4 ± 0.002 | 6.6 ± 0.36 | 6.16 ± 0.09 | 65 | 2.5 ± 0.011 | 2.7 ± 0.032 | 2.06 ± 0.18 | 2.22 ± 0.01 | 3.31 ± 0.08 | 3.2 ± 0.44 | 2.02 ± 0.14 | 0.76 ± 0.005 | 0.62 ± 0.001 | 0.58 ± 0.002 | 0.41 ± 0.001 | 11.39 ± 0.95 | 6.58 ± 0.17 | 80 | 2.6 ± 0.025 | 3.3 ± 0.013 | 2.19 ± 0.02 | 2.32 ± 0.04 | 3.55 ± 0.16 | 3.4 ± 0.75 | 2.12 ± 0.19 | 0.82 ± 0.002 | 0.65 ± 0.007 | 0.61 ± 0.01 | 0.48 ± 0.0018 | 29.54 ± 1.29 | 6.75 ± 0.11 |
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