Antioxidant and Hepatoprotective Effects of Fig Fruit Extract with Olive Oil and Date-Palm Fruit Extract on Hepatic Toxicity of Oral Subchronic Exposure to Some Nanoparticles in Wistar Rats

Figure 5

The effects of fig with olive oil and date-palm fruit extracts (FOD) on the microscopic histological appearance of livers treated with different nanoparticles (NPs) for 75 days. (a) Higher power view of the control liver showing average central veins (CV) and average hepatocytes in peri-venular area (black arrow) with average blood sinusoids (Si); (b) FOD-treated group showing average portal tracts (PT) with average portal veins (PV), average bile ducts (BD), and average hepatocytes in peri-portal area (black arrow); (c) SiO₂NPs-treated group showing portal tracts with mild portal inflammatory infiltrate (black arrow), average portal vein (PV), and scattered apoptotic hepatocytes in peri-portal area (blue arrow); (d) FOD-SiO₂NPs-treated group showing average central veins (CV) and average hepatocytes in peri-venular area (black arrow); (e) Al₂O₃NPs-treated group showing portal tracts with mild portal inflammatory infiltrate (black arrow) with mildly dilated congested portal veins (PV), average bile ducts (BD), and average hepatocytes in peri-portal area (blue arrow); (f) FOD-Al₂O₃NPs-treated group showing average portal tracts (PT) with average portal veins (PV), average bile ducts (BD), and average hepatocytes in peri-portal area (black arrow); (g) ZnO NPs-treated group showing mildly edematous portal tracts (PT) with markedly dilated congested portal veins (PV), average bile ducts (BD), and moderate apoptotic hepatocytes in peri-portal area (black arrow); (h) FOD-ZnO NPs-treated group showing mildly edematous portal tracts (PT) with mildly dilated portal veins (PV), average hepatic artery (HA), and few scattered apoptotic hepatocytes in peri-portal area (black arrow).