Antioxidant and Hepatoprotective Effects of Fig Fruit Extract with Olive Oil and Date-Palm Fruit Extract on Hepatic Toxicity of Oral Subchronic Exposure to Some Nanoparticles in Wistar Rats

Table 3

The effects of fig with olive oil and date-palm fruit extract on the liver histopathological results of male rats treated with silicon oxide nanoparticles, aluminum oxide nanoparticles, or zinc oxide nanoparticles for 75 days.

	Portal tract				Peri-venular area
	PV	Inflammatory infiltrate	Edema	Hepatocytes	CV	Blood sinusoids	Hepatocytes	Inflammatory infiltrate
Control	0	0	0	0	0	0	0	0
SiO2NPs	++	0	+	++	++	+	++	0
FOD-SiO2NPs	+	0	+	+	0	0	0	0
Al2O3NPs	+	+	0	+	0	0	0	0
FOD-Al2O3NPs	0	0	0	0	0	+	0	0
ZnONPs	0	+	0	+	+	0	+	0
FOD-ZnONPs	0	0	0	0	0	0	+	0

FOD, fig with olive oil and date-palm fruit extracts; SiO₂NPs, silicon oxide nanoparticles; Al₂O₃NPs, aluminum oxide nanoparticles; ZnONPs, zinc oxide nanoparticles. Portal tract: portal vein (PV): 0: average, +: mildly dilated/congested, ++: markedly dilated/congested. Inflammatory infiltrate: 0: no, +: mild, ++: moderate/marked. Edema: 0: no, +: mild, ++: moderate/marked. Hepatocytes: 0: average, +: few/scattered apoptoses, ++: marked apoptosis. Peri-venular area: central vein: 0: average, +: mildly dilated/congested, ++: markedly dilated/congested. Blood sinusoids: 0: average, +: mildly dilated/congested, ++: markedly dilated/congested. Hepatocytes: 0: average, +: few/scattered apoptoses, ++: marked apoptosis. Inflammatory infiltrate: 0: no, +: mild, ++: moderate/marked.