Journal of Food Quality

Research Article

Determination of 60 Food-Borne Stimulant Drug Residues in Animal-Derived Foods by Solid-Phase Extraction Purification and Ultra-High-Performance Liquid Chromatography-Quadrupole/Orbitrap High-Resolution Mass Spectrometry

Table 1

MRM parameters and chemical abstracts service (CAS) of 60 food-borne stimulants.
Category (number)CompoundMolecular formulaCASRetention time (min)Adduct/chargeParent ion (m/z)Delta (×10−6)Measured mass of fragment ions (m/z)
Measured mass (m/z)Theoretical mass (m/z)
β2 adrenoceptor agonists (18)ClenbuterolC12H18Cl2N2O129138-58-54.60[M + H]+277.0866277.08660.00203.01384; 132.06825; 168.04498; 259.07632
SalbutamolC13H21NO318559-94-92.76[M + H]+240.1592240.1591−0.51148.07571; 166.08632; 222.14890; 121.06477
RactopamineC18H23NO397825-25-74.20[M + H]+302.1748302.1748−0.09107.04913; 121.06482; 164.10710; 136.07576
TerbutalineC12H19NO323031-25-62.74[M + H]+226.1435226.1435−0.07152.07060; 125.05965; 107.04907; 170.08112
FenoterolC17H21NO413392-18-23.36[M + H]+304.154304.154−0.09107.04907; 135.08043; 152.07059; 286.14392
TulobuterolC12H18ClNO41570-61-04.75[M + H]+228.1147228.11470.20228.23235; 155.02596; 172.05254; 137.01540
PenbutololC18H29NO236507-48-913.09[M + H]+292.2269292.2269−0.01236.16449; 74.06004; 133.06476; 201.12735
CimaterolC12H17N3O54239-37-12.74[M + H]+220.1441220.14420.48160.08694; 143.06039; 202.13390; 116.04941
SalmeterolC25H37NO489365-50-413.57[M + H]+416.2792416.2792−0.0191.05419; 232.16962; 380.25836; 398.26859
AtenololC14H22N2O329122-68-72.84[M + H]+267.1703267.1699−1.49145.06473; 74.06001; 190.08615; 56.04948
MetoprololC15H25NO381024-43-34.69[M + H]+268.1905268.1904−0.3474.06007; 116.10698; 121.06484; 56.04953
ClenproperolC11H16Cl2N2O38339-11-64.13[M + H]+263.0708263.07090.23245.06088; 132.06830; 203.01390; 168.04503
Demethyl coclaurineC16H17NO35843-65-23.21[M + H]+272.1279272.1280.11107.04911; 255.10164; 161.05980; 143.04921
TretoquinolC19H23NO518559-59-64.18[M + H]+346.1645346.1644−0.26164.07080; 228.82471; 137.05959
PropanololC16H21NO2525-66-67.25[M + H]+260.1644260.1644−0.12116.10688; 74.06000; 183.08038; 56.04948
BromoclenbuterolC12H18BrClN2O37153-52-94.80[M + H]+321.0364321.0361−0.96246.96312; 168.04482; 132.06813
FormoterolC19H24N2O473573-87-24.72[M + H]+345.1809345.1804−1.33121.06469; 149.09604; 91.05414
BrombuterolC12H18Br2N2O41937-02-45.09[M + H]+364.9859364.9855−0.89211.99431; 290.91266; 132.0618
Glucocorticoids (9)MeprednisoneC21H26O553-03-29.51[M + H]+359.185359.1849−0.18147.08055; 171.08052; 237.12759; 159.08061
PrednisoloneC21H28O550-24-89.97[M + H]+361.201361.2007−0.76147.08084; 228.82837; 121.06483; 171.08055
MethylprednisoloneC22H30O583-43-212.45[M + H]+375.2163375.2162−0.33147.08047; 121.06472; 135.08029; 357.19714
DexamethasoneC22H29FO550-02-212.44[M + H]+393.2072393.2069−0.92147.08052; 228.82304; 322.25323; 121.06493
BetamethasoneC22H29O5F378-44-912.69[M + H]+393.21393.21−0.94322.25394; 228.83580; 90.97672; 251.16698
BeclomethasoneC22H29ClO54419-39-013.33[M + H]+409.1774409.1773−0.15228.82869; 147.08031; 279.17426; 121.06482
FludrocortisoneC21H29FO5127-31-110.01[M + H]+381.2069381.2068−0.24228.83195; 181.10197; 239.14240; 325.17957
HydrocortisoneC21H30O550-23-710.05[M + H]+363.2162363.21630.08121.06479; 97.06477; 327.19553; 267.17416
CortisoneC21H28O553-06-59.73[M + H]+361.2006361.20060.09163.11180; 121.06477; 105.06985; 145.10123
Protein anabolic agents (18)ZilpaterolC14H19N3O2117827-79-92.72[M + H]+262.1552262.1546−2.32185.07091; 244.14441; 202.09747; 157.07603
StanozololC21H32N2O10418-03-817.78[M + H]+329.2587329.2584−0.8498.98405; 81.04475; 228.83578; 107.08548
TrenboloneC18H22O210161-33-813.81[M + H]+271.1693271.169−1.34253.15874; 199.11179; 227.14310
MetandienoneC20H28O272-63-915.95[M + H]+301.2162301.2159−0.82121.06470; 149.13242; 283.20560; 107.08543
17-MethyltestosteroneC20H30O258-18-417.48[M + H]+303.2319303.2315−1.4097.06470; 109.06471; 285.22119
TestosteroneC19H28O258-22-016.63[M + H]+289.2162289.2159−1.1797.06470; 109.6470; 253.19521
NandroloneC18H26O2434-22-015.04[M + H]+275.2006275.2003−0.99109.06473; 257.18994; 239.17946; 83.04912
Testosterone propionateC22H32O357-85-219.19[M + H]+345.2424345.2421−0.8897.06470; 109.06470; 121.06471;
Nandrolone 17-propionateC21H30O37207-92-319.01[M + H]+331.2268331.2266−0.7564.97739; 301.17001; 257.18979; 109.06461
BoldenoneC19H26O2846-48-014.5[M + H]+287.2006287.2004−0.52121.06473; 135.11676; 173.09605
Nandrolone phenylpropionateC27H34O362-90-819.45[M + H]+407.2581407.2579−0.46105.06976; 257.18985; 91.05414
DehydroepiandrosteroneC19H28O253-43-016.68[M + H]+271.2056271.2055−0.61253.19475; 97.06460; 109.06458; 81.06975
ZeranolC18H26O526538-44-315.46[M − H]−321.1707321.17080.30277.18091; 303.16013; 259.17023
Beta-zearalanolC18H26O542422-68-412.83[M − H]−321.1708321.17090.28277.189097; 303.16031; 259.17044
Alpha-zearalenolC18H24O536455-72-816.03[M − H]−319.1551319.15520.35275.16528; 160.01668; 130.04247
Beta-zearalenolC18H24O571030-11-013.36[M − H]−319.1551319.15530.48275.16531; 160.01660; 130.04247; 301.14468
ZearalanoneC18H24O55975-78-017.15[M − H]−319.155319.1550.00275.16534; 205.08704; 107.05029; 164.09731
ZearalenoneC18H22O517924-92-417.26[M − H]−317.14317.140.01131.05035; 175.04012; 112.98568; 273.14966
Diuretics (12)AcetazolamideC4H6N4O3S259-66-53.34[M − H]−220.98220.980.5383.02512; 192.92908; 220.98090; 57.97578
CanrenoneC22H28O3976-71-617.52[M + H]+341.2111341.21108−0.98107.08548; 187.11177; 97.06478
ChlortalidoneC14H11ClN2O4S77-36-15.89[M − H]−337.01337.010.19146.02484; 189.97359; 79.98119; 318.99512
FurosemideC12H11ClN2O5S54-31-99.33[M − H]−329.000329.00000.45204.98441; 285.01059; 77.96552; 126.01163
SpironolactoneC22H28O352-01-717.22[M + H]+341.2111341.2108−0.80107.08548; 187.11177; 97.0678; 169.10120
BendroflumethiazideC15H14F3N3O4S273-48-311.77[M − H]−420.0305420.0304−0.22289.04532; 327.96802; 196.98270; 77.96552
ChlorothiazideC7H6ClN3O4S258-94-63.4[M − H]−293.9417293.9416−0.31213.96100; 228.83432; 112.98554
HydrochlorothiazideC7H8ClN3O4S258-93-53.56[M − H]−295.96295.962.8877.96552; 204.98441; 268.94629; 215.95763
TriamtereneC12H11N7396-01-04.08[M + H]+254.1149254.1146−1.15237.08849; 195.06674; 104.04945; 168.05598
4-Amino-6-chlorobenzene-1,3-disulfonamideC6H8ClN3O4S2121-30-22.97[M − H]−283.9572283.95720.0577.96553; 204.98445; 169.00778; 136.05168
BumetanideC17H20N2O5S28395-03-116.71[M + H]+365.1166365.1162−1.18240.13828; 184.07570; 156.08081; 196.07573
TorasemideC16H20N4O3S56211-40-67.92[M + H]+349.1329349.1327−0.51264.08023; 183.09180; 290.05991; 168.06827
β-Receptor antagonists (3)AcebutololC18H28N2O434381-68-54.51[M + H]+337.212233732119−0.79116.10677; 228.82957; 72.08070; 319.20129
CelipololC20H33N3O457470-78-75.26[M + H]+380.3109389.3104−1.2274.06003; 324.19189; 307.16522; 251.10277
NebivololC22H25F2NO4152520-56-412.34[M + H]+406.1824406.1821−0.84151.05531; 123.06033; 228.83768; 103.05408