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Journal of Healthcare Engineering
Volume 2017, Article ID 9547896, 8 pages
https://doi.org/10.1155/2017/9547896
Research Article

Gentamicin Released from Porous Scaffolds Fabricated by Stereolithography

1Biomedical Engineering Research Unit, National Metal and Materials Technology Center, Pathum Thani 12120, Thailand
2Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand

Correspondence should be addressed to Siriporn Tanodekaew; ht.ro.cetm@nropiris

Received 12 April 2017; Accepted 31 July 2017; Published 20 August 2017

Academic Editor: John S. Katsanis

Copyright © 2017 Somruethai Channasanon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Porous oligolactide-hydroxyapatite composite scaffolds were obtained by stereolithographic fabrication. Gentamicin was then coated on the scaffolds afterwards, to achieve antimicrobial delivery ability to treat bone infection. The scaffolds examined by stereomicroscope, SEM, and μCT-scan showed a well-ordered pore structure with uniform pore distribution and pore interconnectivity. The physical and mechanical properties of the scaffolds were investigated. It was shown that not only porosity but also scaffold structure played a critical role in governing the strength of scaffolds. A good scaffold design could create proper orientation of pores in a way to strengthen the scaffold structure. The drug delivery profile of the porous scaffolds was also analyzed using microbiological assay. The release rates of gentamicin from the scaffolds showed prolonged drug release at the levels higher than the minimum inhibitory concentrations for S. aureus and E. coli over a 2-week period. It indicated a potential of the scaffolds to serve as local antibiotic delivery to prevent bacterial infection.