Mitofusin-2 Restrains Hepatic Stellate Cells’ Proliferation via PI3K/Akt Signaling Pathway and Inhibits Liver Fibrosis in Rats

Figure 5

Protein expression of p-PDGFR-β, TGF-β1, α-SMA, and Col-1 increased while Mfn-2 decreased gradually under the influence of CCl₄. (a) Protein expressions of Mfn-2, p-PDGFR-β, TGF-β1, α-SMA, and Col-1 of each group at the 14^th, 28^th, 42^nd and 56^th days after the first injection of CCl₄/olive oil detected by western blot. (b) Protein expressions and their location in liver tissue of p-PDGFR-β, α-SMA, and Col-1 of each group detected by immunohistochemical staining (magnification × 200).

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