Table of Contents Author Guidelines Submit a Manuscript
Developmental Immunology
Volume 6 (1998), Issue 3-4, Pages 233-243
http://dx.doi.org/10.1155/1998/73401

Glucocorticoids Induce a TH2 Response In Vitro

Medical Research Council, Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK

Received 15 August 1996; Accepted 23 August 1997

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [37 citations]

The following is the list of published articles that have cited the current article.

  • Jonathan D. Ashwell, Frank W. M. Lu, and Melanie S. Vacchio, “Glucocorticoids in T Cell Development and Function*,” Annual Review of Immunology, vol. 18, no. 1, pp. 309–345, 2000. View at Publisher · View at Google Scholar
  • Francisco Ramírez, and Don Mason, “Induction of resistance to active experimental allergic encephalomyelitis by myelin basic protein-specific Th2 cell lines generated in the presence of glucocorticoids and IL-4,” European Journal of Immunology, vol. 30, no. 3, pp. 747–758, 2000. View at Publisher · View at Google Scholar
  • Philippe Kourilsky, and Paolo Truffa-Bachi, “Cytokine fields and the polarization of the immune response,” Trends in Immunology, vol. 22, no. 9, pp. 502–509, 2001. View at Publisher · View at Google Scholar
  • Peter J. Barnes, “Corticosteroids, IgE, and atopy,” Journal of Clinical Investigation, vol. 107, no. 3, pp. 265–266, 2001. View at Publisher · View at Google Scholar
  • B. Spellberg, and J. E. Edwards, “Type 1/Type 2 Immunity in Infectious Diseases,” Clinical Infectious Diseases, vol. 32, no. 1, pp. 76–102, 2001. View at Publisher · View at Google Scholar
  • Mills, Ryan, LaCourse, and North, “Extensive Mycobacterium bovis BCG infection of liver parenchymal cells in immunocompromised mice,” Infection and Immunity, vol. 69, no. 5, pp. 3175–3180, 2001. View at Publisher · View at Google Scholar
  • Armelle Biola, Philippe Lefebvre, Mallory Perrin-Wolff, Marie Sturm, Jacques Bertoglio, and Marc Pallardy, “Interleukin-2 inhibits glucocorticoid receptor transcriptional activity through a mechanism involving STAT5 (signal transducer and activator of transcription 5) but not AP-1,” Molecular Endocrinology, vol. 15, no. 7, pp. 1062–1076, 2001. View at Publisher · View at Google Scholar
  • K.A Skjolaas, and J.E Minton, “Does cortisol bias cytokine production in cultured porcine splenocytes to a Th2 phenotype?,” Veterinary Immunology and Immunopathology, vol. 87, no. 3-4, pp. 451–458, 2002. View at Publisher · View at Google Scholar
  • Marc Y Engelsma, Mark O Huising, Willem B van Muiswinkel, Gert Flik, Jimmy Kwang, Huub F.J Savelkoul, and B.M.Lidy Verburg-van Kemenade, “Neuroendocrine–immune interactions in fish: a role for interleukin-1,” Veterinary Immunology and Immunopathology, vol. 87, no. 3-4, pp. 467–479, 2002. View at Publisher · View at Google Scholar
  • K.A. Skjolaas, D.M. Grieger, C.M. Hill, and J.E. Minton, “Glucocorticoid regulation of type 1 and type 2 cytokines in cultured porcine splenocytes,” Veterinary Immunology and Immunopathology, vol. 87, no. 1-2, pp. 79–87, 2002. View at Publisher · View at Google Scholar
  • Rok Gaspersic, Draga Stiblar-Martincic, and Uros Skaleric, “Influence of restraint stress on ligature-induced periodontitis in rats,” European Journal of Oral Sciences, vol. 110, no. 2, pp. 125–129, 2002. View at Publisher · View at Google Scholar
  • Lavjay Butani, “Corticosteroid-induced hypersensitivity reactions,” Annals of Allergy, Asthma & Immunology, vol. 89, no. 5, pp. 439–445, 2002. View at Publisher · View at Google Scholar
  • Emira Ayroldi, Ornella Zollo, Antonio Macchiarulo, Barbara Di Marco, Cristina Marchetti, and Carlo Riccardi, “Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1,” Molecular and Cellular Biology, vol. 22, no. 22, pp. 7929–7941, 2002. View at Publisher · View at Google Scholar
  • Amany Zekry, G.Alex Bishop, David G. Bowen, Margaret M. Gleeson, Seven Guney, Dorothy M. Painter, and Geoffrey W. McCaughan, “Intrahepatic cytokine profiles associated with posttransplantation hepatitis C virus-related liver injury,” Liver Transplantation, vol. 8, no. 3, pp. 292–301, 2002. View at Publisher · View at Google Scholar
  • Carlo Riccardi, Stefano Bruscoli, and Graziella Migliorati, “Molecular mechanisms of immunomodulatory activity of glucocorticoids,” Pharmacological Research, vol. 45, no. 5, pp. 361–368, 2002. View at Publisher · View at Google Scholar
  • Jeffrey K. Actor, Jessica Indrigo, Christopher M. Beachdel, Margaret Olsen, Alice Wells, Robert L. Hunter Jr., and Amitava Dasgupta, “Mycobacterial glycolipid cord factor trehalose 6,6′-dimycolate causes a decrease in serum cortisol during the granulomatous response,” NeuroImmunoModulation, vol. 10, no. 5, pp. 270–282, 2002. View at Publisher · View at Google Scholar
  • Michael Bailey, Harald Engler, John Hunzeker, and John F. Sheridan, “The Hypothalamic-Pituitary-Adrenal Axis and Viral Infection,” Viral Immunology, vol. 16, no. 2, pp. 141–157, 2003. View at Publisher · View at Google Scholar
  • V.L. Clifton, and V.E. Murphy, “Maternal Asthma as a Model for Examining Fetal Sex-specific Effects on Maternal Physiology and Placental Mechanisms that Regulate Human Fetal Growth,” Placenta, vol. 25, pp. S45–S52, 2004. View at Publisher · View at Google Scholar
  • Tetsuo Takada, Nobuo Yoshinari, Shin Sugiishi, Hitoshi Kawase, Takashi Yamane, and Toshihide Noguchi, “Effect of Restraint Stress on the Progression of Experimental Periodontitis in Rats,” Journal of Periodontology, vol. 75, no. 2, pp. 306–315, 2004. View at Publisher · View at Google Scholar
  • Iftikhar Hussain, and Joel N. Kline, “DNA, the Immune System, and Atopic Disease,” Journal of Investigative Dermatology Symposium Proceedings, vol. 9, no. 1, pp. 23–28, 2004. View at Publisher · View at Google Scholar
  • Fulvio Mastrandrea, “The potential role of allergen-specific sublingual immunotherapy in atopic dermatitis,” American Journal of Clinical Dermatology, vol. 5, no. 5, pp. 281–294, 2004. View at Publisher · View at Google Scholar
  • Jacqueline Poot, Matthew E. Rogers, Paul A. Bates, and Arno Vermeulen, “Detailed analysis of an experimental challenge model for Leishmania infantum (JPC strain) in dogs,” Veterinary Parasitology, vol. 130, no. 1-2, pp. 41–53, 2005. View at Publisher · View at Google Scholar
  • Tanja Lange, Stoyan Dimitrov, Horst-Lorenz Fehm, and Jan Born, “Sleep-like concentrations of growth hormone and cortisol modulate type1 and type2 in-vitro cytokine production in human T cells,” International Immunopharmacology, vol. 6, no. 2, pp. 216–225, 2006. View at Publisher · View at Google Scholar
  • Ana C. Liberman, Jimena Druker, Marcelo J. Perone, and Eduardo Arzt, “Glucocorticoids in the regulation of transcription factors that control cytokine synthesis,” Cytokine & Growth Factor Reviews, vol. 18, no. 1-2, pp. 45–56, 2007. View at Publisher · View at Google Scholar
  • Fonfara, Siebert, Prange, and Colijn, “The impact of stress on cytokine and haptoglobin mRNA expression in blood samples from harbour porpoises (Phocoena phocoena),” Journal of the Marine Biological Association of the United Kingdom, vol. 87, no. 1, pp. 305–311, 2007. View at Publisher · View at Google Scholar
  • Xiaoqin Wang, Richard F. Lockey, Subhra Mohapatra, Shyam S. Mohapatra, Weidong Xu, Xiaoyuan Kong, Dongqing Chen, Gary Hellermann, Terry A. Ahlert, Joseph D. Giaimo, Stephania A. Cormier, and Xu Li, “Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma,” Respiratory Research, vol. 10, 2009. View at Publisher · View at Google Scholar
  • Ana C. Liberman, Jimena Druker, Damian Refojo, Florian Holsboer, and Eduardo Arzt, “Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells,” FASEB Journal, vol. 23, no. 5, pp. 1558–1571, 2009. View at Publisher · View at Google Scholar
  • Ana C. Liberman, Jimena Druker, Fernando Aprile Garcia, Florian Holsboer, and Eduardo Arzt, “Intracellular Molecular Signaling,” Annals of the New York Academy of Sciences, vol. 1153, no. 1, pp. 6–13, 2009. View at Publisher · View at Google Scholar
  • Mauro Perretti, and Fulvio D'Acquisto, “Annexin A1 and glucocorticoids as effectors of the resolution of inflammation,” Nature Reviews Immunology, vol. 9, no. 1, pp. 62–70, 2009. View at Publisher · View at Google Scholar
  • Jehyeon Ra, Sanggon Lee, Hye Jin Kim, Young Pyo Jang, Hyunjong Ahn, and Jinju Kim, “Bambusae Caulis in Taeniam extract reduces ovalbumin-induced airway inflammation and T helper 2 responses in mice,” Journal of Ethnopharmacology, vol. 128, no. 1, pp. 241–247, 2010. View at Publisher · View at Google Scholar
  • A.M. Beasley, L.P. Kahn, and R.G. Windon, “The periparturient relaxation of immunity in Merino ewes infected with Trichostrongylus colubriformis: Endocrine and body compositional responses,” Veterinary Parasitology, vol. 168, no. 1-2, pp. 51–59, 2010. View at Publisher · View at Google Scholar
  • C.T. Collier, T.H. Welsh, J.A. Carroll, and J.C. Laurenz, “Insulin-like growth factor-1 attenuates glucocorticoid suppression of pig lymphocyte function,” Food and Agricultural Immunology, vol. 22, no. 4, pp. 311–323, 2011. View at Publisher · View at Google Scholar
  • A.M. Beasley, L.P. Kahn, and R.G. Windon, “The influence of reproductive physiology and nutrient supply on the periparturient relaxation of immunity to the gastrointestinal nematode Trichostrongylus colubriformis in Merino ewes,” Veterinary Parasitology, vol. 188, no. 3-4, pp. 306–324, 2012. View at Publisher · View at Google Scholar
  • Tomasz Maslanka, and Jerzy Jan Jaroszewski, “In vitro effects of dexamethasone on bovine CD25+CD4+ and CD25−CD4+ cells,” Research in Veterinary Science, vol. 93, no. 3, pp. 1367–1379, 2012. View at Publisher · View at Google Scholar
  • Tomasz Maslanka, and Jerzy Jan Jaroszewski, “In vitro studies on the influence of dexamethasone and meloxicam on bovine WC1+ γδ T cells,” Veterinary Immunology and Immunopathology, vol. 151, no. 3-4, pp. 248–262, 2013. View at Publisher · View at Google Scholar
  • Kate E. Mounsey, Hugh C. Murray, Helle Bielefeldt-Ohmann, Cielo Pasay, Deborah C. Holt, Bart J. Currie, Shelley F. Walton, and James S. McCarthy, “Prospective Study in a Porcine Model of Sarcoptes scabiei Indicates the Association of Th2 and Th17 Pathways with the Clinical Severity of Scabies,” Plos Neglected Tropical Diseases, vol. 9, no. 3, 2015. View at Publisher · View at Google Scholar
  • Yinglu Feng, Chunbin Wang, Silu Cheng, Xiaorong Wang, Xianze Meng, Lujia Li, Juan Du, Qun Liu, Yuyu Guo, Yongbin Meng, Binbin Cheng, and Changquan Ling, “Ginsenoside Rh1 Improves the Effect of Dexamethasone on Autoantibodies Production and Lymphoproliferation in MRL/lpr Mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar