costimulatori signal provid cell requir cell produc specif antibodi tdepend antigen have investig suitabl use cd40 cultur system prolifer differenti agspecif human cell use cytomegalovirus cmv tetanus toxoid antigen modifi cd40 cultur system cd32 transfect cell anticd40 il4 appli sequenti cytokin stimul compar total bcell cultur antigenspecif cell preselect pan the detect specif antibodi becam possibl when antigenselect cell were cultur 7 day cd40 system induc clonal expans follow addit il2 il10 addit 7 day induc plasmacel differenti conclud our intial inabl detect specif antibodi cd40 system due overgrowth nonspecif cell clone select antigenspecif cell pan overcom problem induction antigenspecif antibodi product found optim when initi contact antigen dure pan limit between 1 24 hour

B. M. Schilizzi

M. C. Harmsen

T. H. The

L. De Leij

Studies on the Induction of Antigen-Specific Antibody in Anti-CD40 Cultured Human B Lymphocytes

the interact cd40 cd40l have been known some time critic regul bcell respons respect prolifer isotyp switch antibodi product memori format more recent find demonstr cd40 can express sever other antigenpres cell apc type macrophag dendrit cell fibroblast this express cd40 regul tcellapc interact central involv wide array inflammatori event here current avail data review demonstr cd40 cd40l interact oper two chronic inflammatori clinic condit name multipl sclerosi atherosclerosi the function correl interact discuss light recent other find shed light multipl effect cd40 cd40l interact

Jon D. Laman

Mark De Boer

Bert A. 'T Hart

CD40 in Clinical Inflammation: From Multiple Sclerosis to Atherosclerosis

the celladhes molecul origin describ nervous system has recent been detect cd4 lymphocyt peripher lymphocyt granulocyt human immun system similar leucocyt type murin immun system mediat neural recognit 2 2 independ homophil bind human murin immun system bind classic vitronectin receptor 3 fibronectin receptor 5 1 respect abstain from homophil bind homophil bind probabl involv antiparallel align sever interact domain integrin bind mediat short segment immunoglobulinlik domain 6 which includ two rgd repeat rodent one rgd motif human modul activ leucocyt vitro parallel lselectin divers cell type releas intact vivo vitro releas can bind laminin adher extracellular matrix sciatic nerv m21 melanoma possibl spleen other tissu can support integrindepend cell migrat preliminari data implic tumor develop transnod lymphocyt migrat

Guni  Kadmon

Anthony M. P. Montgomery

Peter  Altevogt

L1 Makes Immunological Progress by Expanding Its Relations

the abil human tonsillar lymphoid cell express growth hormon receptor hghnr analyz flow cytometri fitccoupl recombin human growth hormon hghn use reveal receptor combin phenotyp markersunlik cell tonsillar cell constitut express hghn receptor quiescent cell separ from activ cell percollgradi centrifug bear fewer receptor than activ one activat cell express hghnr typic germin centr cd4 cd57 cell these latter thus appear fulli activatedinsid lymph follicl germin centr cd38 bcell popul mantlezon cd39 bcell popul display similar level hghnr express receptor densiti lower divid darkzon cd38 cd10 cellsdiffer lymphoidcel popul thus differ mark abil express growth hormon receptor relat notabl activ status this highlight link between neuroendocrin system activ immun defens

Olivier Thellin

Bernard Coumans

Willy Zorzi

Ross Barnard

Georges Hennen

Ernst Heinen

Ahmed Igout

Expression of Growth Hormone Receptors by Lymphocyte subpopulations in the Human tonsil

L. V. Rizzo

E. A. Secord

V. K. Tsiagbe

D. T. Umetsu

R. H. Dekruyff

W. J. Simmons

G. J. Thorbecke

Components Essential for the Generation of Germinal Centers

the microenviron secondari lymphoid organ consist two major popul cell lymphoid cell popul stromal cell contribut both tissu architectur function interact both popul essenti develop control humor immun respons studi stromalcel prepar were obtain multistag process this involv cultur 300400 slice human tonsil 68 day 25 trypsin digest residu explant follow cd45positivecel deplet use magnet bead final period cultur 4 day remov remain nonadher cell phenotypifig panel monoclon antibodi reveal cell express hladr cd54 icam1 cd44 cd45 nor rang other marker epitheli endotheli cell immunoassay supernat from stromal cell reveal il6 produc constitut it product increas treatment tnf ifn contrast il1 il2 il4 il7 il8 il10 il12 tnf ifn were produc function test show cell express follicular dendrit celllik properti cocultur tonsilar cell stromal cell result enhanc prolifer also led increas product immunoglobulin il6 suggest crucial signal between popul

Grzegorz Skibinski

Anna Skibinska

Martine Deckers

Keith James

Tonsil Stromal-Cell Lines Expressing FDC-Like Properties: Isolation, Characterization, and Interaction with B Lymphocytes

have recent report thymic lymphocyt tbl first bcell subpopul undergo isotyp switch igg iga dure embryon life the aim studi analyz influenc antigen stimul tbl locat activ use germfre newborn pig model which matern antibodi antigen affect bcell develop immunohistolog analysi show tbl were dissemin main thymic medulla there were differ distribut tbl both newborn piglet befor after colon escherichia coli older convent rear conv piglet the number immunoglobulin secret cell measur elispot method influenc microflora food antigen igmposit cell secret igm cd45rcposit cell spontan produc igm igg iga were detect newborn thymusour find suggest tbl differenti switch igg igasecret cell influenc extern antigen thymic microenviro play import role process

B. Cukrowska

I. Trebichavský

P. Rossmann

Z. Reháková

J. ŠInkora

K. Haverson

R. Lodinová-Žádníková

H. Tlaskalová-Hogenová

Antigenic Stimuli do not Influence Thymic B Lymphocytes: A Morphological and Functional Study in
Germ-Free and Conventionally Reared Piglets

mice inactiv tnflt gene have profound abnorm immun system hypoimmunoglobulinaemia lack lymph node undifferenti spleen defect class switch transplant bone marrow cell from wildtyp mice restor synthesi tnf correct splenic microarchitectur repopul lamina propria igaproduc plasma cell normal serum immunoglobulin level tnflt defici mice furthermor format germin center spleen defect class switch respons tcelldepend antigen correct these data demonstr most tnfproduc cell bonemarrowderiv immunodefici due tnflt delet can correct larg extent normal bone marrow cell transplant

Bernhard  Ryffel

Michel Le Hir

Mathias  Müller

Hans-Pietro  Eugster

Correction of the TNF-LT&#945;-Deficient Phenotype by Bone Marrow Transplantation

intrathym tcell differenti under control thymic microenviron which act matur thymocyt via membran well solubl product increas data show process can modul classic hormon exemplifi herein prolactin prl growth hormon larg secret pituitari glandboth prl stimul secret thymulin thymic hormon produc thymic epitheli cell convers low level circul thymulin parallel hypopituitari state interest enhanc effect thymulin seem mediat insulinlik growth factor igf1 sinc can abrog antiigf1 antiigflreceptor antibodi the influenc prl thymic epithelium pleiotrop prl enhanc vivo express highmolecularweight cytokeratin stimul vitro tec prolifer effect share igf1differenti cell also target intrathym action prl vivo inocul rat pituitari cell line old rat result restor thymus includ differenti cd4 cd8 thymocyt cd4 cd8 cell furthermor prl may regul mainten thymocyt viabil dure doubleposit stage thymocyt differentiationinject age mice increas total thymocyt number percentag cd3bear cell well concanavalina mitogen respons il6 product thymocyt interest similar find observ anim treat igf1 last thymic hypoplasia observ dwarf mice can revers treatmentin keep data summar earlier detect receptor prl both thymocyt thymic epitheli cell important recent studi indic both cell type can produc prl intrathym similar product igf1 express correspond receptor has also been demonstratedin conclus data strong indic thymus physiolog under control pituitari hormon prl addit classic endocrin pathway paracrin autocrin circuit probabl implic control

Valéria De Mello-Coelho

Wilson Savino

Marie-Catherine Postel-Vinay

Mireille Dardenne

Role of Prolactin and Growth Hormone on Thymus Physiology

the develop cell accompani abil specif enter peripher lymphoid tissu recent describ novel rat monoclon antibodi ibl2 igg2b react 2629kd heterodimer structur cell surfac this mab has been found recogn differenti peripher cell mice depend tissu origin the major splenic cell well matur cell bone marrow were stain mab wherea lymphocyt isol from peyer patch display onli neglig reactiv extend observ analyz relationship between express ibl2 antigen lselect surfac bcell precursor bone marrow multiparamet flow cytometri within b220 posit compart signific differ lselectin express could observ between various ibl2reactiv subset furthermor investig whether evid establish tissueassoci phenotyp heterogen similar found normal mice could found upon adopt transfer normal unselect splenic lymphocyt scid recipi splscid has been found larg part splenic cell preserv ibl2 reactiv wherea cell had lost ibl2 antigen splscid these data indic phenotyp differ within scid mice may result migrat lymphocyt from spleen toward lymph node alter express ibl2 antigen correl process

Péter Balogh

Attila Kumánovics

Istvan Juhasz

Studies on the Tissue-Related Phenotypic Heterogeneity of Murine B Cells

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Journal of Immunology Research provides a platform for scientists and clinicians working in different and diverse areas of immunology and therapy.

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Chief Editor, Professor Holland, has a background focusing on researching the development of conjunctival fibrosis and the characterisation of immune responses to potential C. trachomatis vaccine candidates.

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Journal of Immunology Research | Hindawi

Journal of Immunology Research

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Richard Boyd

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