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Clinical and Developmental Immunology
Volume 2011, Article ID 549023, 8 pages
http://dx.doi.org/10.1155/2011/549023
Research Article

HLA- 57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India

1Rotary-TTK Blood Bank, Bangalore Medical Services Trust (BMST), Bangalore 560075, India
2HIV Services, Seva Free Clinic, Bangalore 560042, India
3Department of Neurovirology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore 560029, India
4Department of Biostatistics, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore 560029, India
5Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore 560029, India
6Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, India
7HLA Laboratory, College of Medicine, University of Cincinnati, Ohio 45267-0550, USA
8Department of Molecular Reproduction, Development and Genetics (MRDG), Indian Institute of Science (IISc), Bangalore 560012, India

Received 28 April 2010; Accepted 2 June 2011

Academic Editor: Stephan Schwander

Copyright © 2011 Latha Jagannathan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Substantial evidence exists for HLA and other host genetic factors being determinants of susceptibility or resistance to infectious diseases. However, very little information is available on the role of host genetic factors in HIV-TB coinfection. Hence, a longitudinal study was undertaken to investigate HLA associations in a cohort of HIV seropositive individuals with and without TB in Bangalore, South India. Methods. A cohort of 238 HIV seropositive subjects were typed for HLA-A, B, and DR by PCR-SSP and followed up for 5 years or till manifestation of Tuberculosis. HLA data of 682 HIV Negative healthy renal donors was used as control. Results. The ratio of males and females in HIV cohort was comparable (50.4% and 49.6%). But the incidence of TB was markedly lower in females (12.6%,) than males (25.6%). Further, HLA-B*57 frequency in HIV cohort was significantly higher among females without TB (21.6%, 19/88) than males (1.7%, 1/59); ; . CD4 counts also were higher among females in this cohort. Conclusion. This study suggests that HIV positive women with HLA-B*57 have less occurrence of TB as compared to males.