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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 135932, 5 pages
Review Article

Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes?

1Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università degli Studi di Palermo, DIBIMEF, Corso Tukory 211, 90100 Palermo, Italy
2Divisione di Reumatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo, 90133 Palermo, Italy

Received 30 April 2011; Revised 29 June 2011; Accepted 30 June 2011

Academic Editor: Anisur Rahman

Copyright © 2012 Giuliana Guggino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation, and SLE. Here, we summarize the findings of recent investigations on TLR and DcR and their role in the immunopathogenesis of the SLE.