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Clinical and Developmental Immunology
Volume 2012, Article ID 284104, 10 pages
http://dx.doi.org/10.1155/2012/284104
Research Article

Herpes Simplex Virus-2 Glycoprotein Interaction with HVEM Influences Virus-Specific Recall Cellular Responses at the Mucosa

1Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
2Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

Received 18 November 2011; Revised 23 February 2012; Accepted 8 March 2012

Academic Editor: Ali A. Ashkar

Copyright © 2012 Sarah J. Kopp et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Xu, M. R. Sternberg, B. J. Kottiri et al., “Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States,” Journal of the American Medical Association, vol. 296, no. 8, pp. 964–973, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Sacks, P. D. Griffiths, L. Corey et al., “HSV shedding,” Antiviral Research, vol. 63, supplement 1, pp. S19–S26, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. P. G. Spear, R. J. Eisenberg, and G. H. Cohen, “Three classes of cell surface receptors for alphaherpesvirus entry,” Virology, vol. 275, no. 1, pp. 1–8, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. P. G. Spear, “Herpes simplex virus: receptors and ligands for cell entry,” Cellular Microbiology, vol. 6, no. 5, pp. 401–410, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Lopez, F. Cocchi, L. Menotti, E. Avitabile, P. Dubreuil, and G. Campadelli-Fiume, “Nectin2α (PRR2α or HveB) and nectin2δ are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D,” Journal of Virology, vol. 74, no. 3, pp. 1267–1274, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Shukla, J. Liu, P. Blaiklock et al., “A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry,” Cell, vol. 99, no. 1, pp. 13–22, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. R. I. Montgomery, M. S. Warner, B. J. Lum, and P. G. Spear, “Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family,” Cell, vol. 87, no. 3, pp. 427–436, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Šedý, P. Spear, and C. Ware, “Cross-regulation between herpesviruses and the TNF superfamily members,” Nature Reviews Immunology, vol. 8, no. 11, pp. 861–873, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Yoon, S. J. Kopp, J. M. Taylor, C. S. Storti, P. G. Spear, and W. J. Muller, “Functional interaction between herpes simplex virus type 2 gD and HVEM transiently dampens local chemokine production after murine mucosal infection,” Plos ONE, vol. 6, no. 1, Article ID e16122, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. M. O. Lasaro, M. O. Diniz, A. Reyes-Sandoval, H. C. Ertl, and L. C. Ferreira, “Anti-tumor DNA vaccines based on the expression of human papillomavirus-16 E6/E7 oncoproteins genetically fused with the glycoprotein D from herpes simplex virus-1,” Microbes and Infection, vol. 7, no. 15, pp. 1541–1550, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. M. O. Lasaro, N. Tatsis, S. E. Hensley et al., “Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses,” Nature Medicine, vol. 14, no. 2, pp. 205–212, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. L. DiMenna, B. Latimer, E. Parzych et al., “Augmentation of primary influenza A virus-specific CD8+ T cell responses in aged mice through blockade of an immunoinhibitory pathway,” Journal of Immunology, vol. 184, no. 10, pp. 5475–5484, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Croft, “Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?” Nature Reviews Immunology, vol. 3, no. 8, pp. 609–620, 2003. View at Google Scholar · View at Scopus
  14. C. Krieg, O. Boyman, Y. X. Fu, and J. Kaye, “B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation,” Nature Immunology, vol. 8, no. 2, pp. 162–171, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Morel, A. Truneh, R. T. Costello, and D. Olive, “LIGHT, a new TNF superfamily member, is essential for memory T helper cell-mediated activation of dendritic cells,” European Journal of Immunology, vol. 33, no. 11, pp. 3213–3219, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Duhen, C. Pasero, F. Mallet, B. Barbarat, D. Olive, and R. T. Costello, “LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation,” European Journal of Immunology, vol. 34, no. 12, pp. 3534–3541, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Tao, L. Wang, K. M. Murphy, C. C. Fraser, and W. W. Hancock, “Regulatory T cell expression of herpesvirus entry mediator suppresses the function of B and T lymphocyte attenuator-positive effector T cells,” Journal of Immunology, vol. 180, no. 10, pp. 6649–6655, 2008. View at Google Scholar · View at Scopus
  18. S. Sakaguchi, “Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self,” Nature Immunology, vol. 6, no. 4, pp. 345–352, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Westmoreland and F. Rapp, “Host range temperature sensitive mutants of herpes simplex virus type 2,” Journal of Virology, vol. 18, no. 1, pp. 92–102, 1976. View at Google Scholar · View at Scopus
  20. J. M. Taylor, E. Lin, N. Susmarski et al., “Alternative entry receptors for herpes simplex virus and their roles in disease,” Cell Host and Microbe, vol. 2, no. 1, pp. 19–28, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Parr, L. Kepple, M. McDermott, M. Drew, J. Bozzola, and E. Parr, “A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2,” Laboratory Investigation, vol. 70, no. 3, pp. 369–380, 1994. View at Google Scholar · View at Scopus
  22. G. Milligan and D. Bernstein, “Generation of humoral immune responses against herpes simplex virus type 2 in the murine female genital tract,” Virology, vol. 206, no. 1, pp. 234–241, 1995. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Gierynska, U. Kumaraguru, S. K. Eo, S. Lee, A. Krieg, and B. T. Rouse, “Induction of CD8 T-cell-specific systemic and mucosal immunity against herpes simplex virus with CpG-peptide complexes,” Journal of Virology, vol. 76, no. 13, pp. 6568–6576, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Stock, C. Jones, W. Heath, and F. Carbone, “CTL response compensation for the loss of an immunodominant class I-restricted HSV-1 determinant,” Immunology and Cell Biology, vol. 84, no. 6, pp. 543–550, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Wallace, R. Keating, W. Heath, and F. Carbone, “The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant,” Journal of Virology, vol. 73, no. 9, pp. 7619–7626, 1999. View at Google Scholar · View at Scopus
  26. W. J. Muller, N. N. Orgun, L. Dong, D. M. Koelle, M. L. Huang, and S. S. Way, “Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2,” Archives of Virology, vol. 153, no. 6, pp. 1165–1169, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Nakanishi, B. Lu, C. Gerard, and A. Iwasaki, “CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help,” Nature, vol. 462, no. 7272, pp. 510–513, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. J. M. Lund, L. Hsing, T. T. Pham, and A. Y. Rudensky, “Coordination of early protective immunity to viral infection by regulatory T cells,” Science, vol. 320, no. 5880, pp. 1220–1224, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. J. R. Groom and A. D. Luster, “CXCR3 in T cell function,” Experimental Cell Research, vol. 317, no. 5, pp. 620–631, 2011. View at Google Scholar · View at Scopus
  30. E. Parr and M. Parr, “Immunoglobulin G is the main protective antibody in mouse vaginal secretions after vaginal immunization with attenuated herpes simplex virus type 2,” Journal of Virology, vol. 71, no. 11, pp. 8109–8115, 1997. View at Google Scholar · View at Scopus
  31. J. E. Blaney Jr., E. Nobusawa, M. A. Brehm et al., “Immunization with a single major histocompatibility complex class I- restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity,” Journal of Virology, vol. 72, no. 12, pp. 9567–9574, 1998. View at Google Scholar · View at Scopus
  32. U. Kumaraguru, M. Gierynska, S. Norman, B. D. Bruce, and B. T. Rouse, “Immunization with chaperone-peptide complex induces low-avidity cytotoxic T lymphocytes providing transient protection against herpes simplex virus infection,” Journal of Virology, vol. 76, no. 1, pp. 136–141, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. E. J. Wherry and R. Ahmed, “Memory CD8 T-cell differentiation during viral infection,” Journal of Virology, vol. 78, no. 11, pp. 5535–5545, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. S. M. Kaech, E. J. Wherry, and R. Ahmed, “Effector and memory T-cell differentiation: implications for vaccine development,” Nature Reviews Immunology, vol. 2, no. 4, pp. 251–262, 2002. View at Google Scholar · View at Scopus
  35. D. N. Mauri, R. Ebner, R. I. Montgomery et al., “LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator,” Immunity, vol. 8, no. 1, pp. 21–30, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. S. A. Marsters, T. M. Ayres, M. Skubatch, C. L. Gray, M. Rothe, and A. Ashkenazi, “Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-κB and AP-1,” Journal of Biological Chemistry, vol. 272, no. 22, pp. 14029–14032, 1997. View at Publisher · View at Google Scholar · View at Scopus
  37. J. R. Sedy, M. Gavrieli, K. G. Potter et al., “B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator,” Nature Immunology, vol. 6, no. 1, pp. 90–98, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. L. C. Gonzalez, K. M. Loyet, J. Calemine-Fenaux et al., “A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 4, pp. 1116–1121, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Cai, A. Anumanthan, J. A. Brown, E. A. Greenfield, B. Zhu, and G. J. Freeman, “CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator,” Nature Immunology, vol. 9, no. 2, pp. 176–185, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Carfí, S. Willis, J. Whitbeck et al., “Herpes simplex virus glycoprotein D bound to the human receptor HveA,” Molecular Cell, vol. 8, no. 1, pp. 169–179, 2001. View at Publisher · View at Google Scholar · View at Scopus
  41. D. M. Compaan, L. C. Gonzalez, I. Tom, K. M. Loyet, D. Eaton, and S. G. Hymowitz, “Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex,” Journal of Biological Chemistry, vol. 280, no. 47, pp. 39553–39561, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. T. C. Cheung, M. W. Steinberg, L. M. Oborne et al., “Unconventional ligand activation of herpesvirus entry mediator signals cell survival,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 15, pp. 6244–6249, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. C. De Trez, K. Schneider, K. Potter et al., “The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin β receptor signaling to achieve homeostasis of dendritic cells,” Journal of Immunology, vol. 180, no. 1, pp. 238–248, 2008. View at Google Scholar · View at Scopus
  44. A. Barakonyi, M. Rabot, A. Marie-Cardine et al., “Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset,” Journal of Immunology, vol. 173, no. 9, pp. 5349–5354, 2004. View at Google Scholar · View at Scopus
  45. P. Soroosh, T. A. Doherty, T. So et al., “Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations,” Journal of Experimental Medicine, vol. 208, no. 4, pp. 797–809, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. G. M. Verjans, R. Q. Hintzen, J. M. van Dun et al., “Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 9, pp. 3496–3501, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Zhu, D. M. Koelle, J. Cao et al., “Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation,” Journal of Experimental Medicine, vol. 204, no. 3, pp. 595–603, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. F. Struyf, C. M. Posavad, E. Keyaerts, M. Van Ranst, L. Corey, and P. G. Spear, “Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals,” Journal of Infectious Diseases, vol. 185, no. 1, pp. 36–44, 2002. View at Publisher · View at Google Scholar · View at Scopus