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Clinical and Developmental Immunology
Volume 2012, Article ID 756353, 24 pages
http://dx.doi.org/10.1155/2012/756353
Review Article

Role of Immune Escape Mechanisms in Hodgkin's Lymphoma Development and Progression: A Whole New World with Therapeutic Implications

1Clinical Oncology Department, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain
2Molecular Biology and Research Section, Hospital de Tortosa Verge de la Cinta and IISPV, URV, 43201 Reus, Spain
3Radiotherapy Department, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain
4Clinical Oncology Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain
5Pathology Department, Hospital de Tortosa Verge de la Cinta and IISPV, URV, 43201 Reus, Spain

Received 26 February 2012; Accepted 5 June 2012

Academic Editor: Keith Knutson

Copyright © 2012 Luis de la Cruz-Merino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hodgkin's lymphoma represents one of the most frequent lymphoproliferative syndromes, especially in young population. Although HL is considered one of the most curable tumors, a sizeable fraction of patients recur after successful upfront treatment or, less commonly, are primarily resistant. This work tries to summarize the data on clinical, histological, pathological, and biological factors in HL, with special emphasis on the improvement of prognosis and their impact on therapeutical strategies. The recent advances in our understanding of HL biology and immunology show that infiltrated immune cells and cytokines in the tumoral microenvironment may play different functions that seem tightly related with clinical outcomes. Strategies aimed at interfering with the crosstalk between tumoral Reed-Sternberg cells and their cellular partners have been taken into account in the development of new immunotherapies that target different cell components of HL microenvironment. This new knowledge will probably translate into a change in the antineoplastic treatments in HL in the next future and hopefully will increase the curability rates of this disease.