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Clinical and Developmental Immunology
Volume 2012, Article ID 808724, 8 pages
http://dx.doi.org/10.1155/2012/808724
Research Article

Adaptive Immunity in Ankylosing Spondylitis: Phenotype and Functional Alterations of T-Cells before and during Infliximab Therapy

1First Department of Pediatrics, Semmelweis University, Bókay János Utca 53-54, 1083 Budapest, Hungary
2Albert Szent-Györgyi Health Center, Department of Rheumatology, University of Szeged, Kálvária sgt. 57, 6725, Szeged, Hungary
3Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences, Bókay János Utca 53-54, 1083 Budapest, Hungary
4Department of Laboratory Medicine, Semmelweis University, Bókay János Utca 53-54, 1083 Budapest, Hungary

Received 1 June 2011; Accepted 14 July 2011

Academic Editor: Peter Szodoray

Copyright © 2012 Balázs Szalay et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Braun and J. Sieper, “Ankylosing spondylitis,” The Lancet, vol. 369, no. 9570, pp. 1379–1390, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. X. Zhang, J. E. Aubin, and R. D. Inman, “Molecular and cellular biology of new bone formation: insights into the ankylosis of ankylosing spondylitis,” Current Opinion in Rheumatology, vol. 15, no. 4, pp. 387–393, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. R. A. Colbert, M. L. Delay, E. I. Klenk, and G. Layh-Schmitt, “From HLA-B27 to spondyloarthritis: a journey through the ER,” Immunological Reviews, vol. 233, no. 1, pp. 181–202, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. I. E. van der Horst-Bruinsma, W. F. Lems, and B. A. Dijkmans, “A systematic comparison of rheumatoid arthritis and ankylosing spondylitis,” Clinical and Experimental Rheumatology, vol. 27, no. 4, supplement 55, pp. S43–S49, 2009. View at Google Scholar
  5. P. T. Yang, H. Kasai, L. J. Zhao, W. G. Xiao, F. Tanabe, and M. Ito, “Increased CCR4 expression on circulating CD4+ T cells in ankylosing spondylitis, rheumatoid arthritis and systemic lupus erythematosus,” Clinical and Experimental Immunology, vol. 138, no. 2, pp. 342–347, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Jandus, G. Bioley, J. P. Rivals, J. Dudler, D. Speiser, and P. Romero, “Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides,” Arthritis and Rheumatism, vol. 58, no. 8, pp. 2307–2317, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Wu, M. Ren, R. Yang et al., “Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+CCR6+Th/Treg cell subset imbalance in ankylosing spondylitis,” Arthritis Research and Therapy, vol. 13, no. 1, article R29, 2011. View at Publisher · View at Google Scholar
  8. G. Nagy, J. M. Clark, E. Buzas et al., “Nitric oxide production of T lymphocytes is increased in rheumatoid arthritis,” Immunology Letters, vol. 118, no. 1, pp. 55–58, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Sieper, J. Braun, M. Rudwaleit, A. Boonen, and A. Zink, “Ankylosing spondylitis: an overview,” Annals of the Rheumatic Diseases, vol. 61, no. 3, pp. iii8–iii18, 2002. View at Google Scholar · View at Scopus
  10. I. Ferkolj, A. Ihan, S. Markovič, Z. Večerič, and M. Pohar, “Infliximab reduces the number of activated mucosal lymphocytes in patients with Crohn's disease,” Journal of Gastrointestinal and Liver Diseases, vol. 15, no. 3, pp. 231–235, 2006. View at Google Scholar · View at Scopus
  11. X. Chen and J. J. Oppenheim, “TNF-α: an activator of CD4+FoxP3+TNFR2+ regulatory T cells,” Current Directions in Autoimmunity, vol. 11, pp. 119–134, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Aeberli, M. Seitz, P. Jüni, and P. M. Villiger, “Increase of peripheral CXCR3 positive T lymphocytes upon treatment of RA patients with TNF-α inhibitors,” Rheumatology, vol. 44, no. 2, pp. 172–175, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Van Der Linden, H. A. Valkenburg, and A. Cats, “Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria,” Arthritis and Rheumatism, vol. 27, no. 4, pp. 361–368, 1984. View at Google Scholar · View at Scopus
  14. S. Garrett, T. Jenkinson, L. G. Kennedy, H. Whitelock, P. Gaisford, and A. Calin, “A new approach to defining disease status in ankylosing spondylitis: the bath ankylosing spondylitis disease activity index,” Journal of Rheumatology, vol. 21, no. 12, pp. 2286–2291, 1994. View at Google Scholar · View at Scopus
  15. G. Mészáros, B. Szalay, G. Toldi et al., “Kinetic measurements using flow cytometry: new methods for Monitoring intracellular processes,” ASSAY and Drug Development Technologies. In press.
  16. A. S. Kaposi, G. Veress, B. Vásárhelyi et al., “Cytometry-acquired calcium-flux data analysis in activated lymphocytes,” Cytometry Part A, vol. 73, no. 3, pp. 246–253, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. R. D. Inman and H. S. El-Gabalawy, “The immunology of ankylosing spondylitis and rheumatoid arthritis: a tale of similarities and dissimilarities,” Clinical and Experimental Rheumatology, vol. 27, no. 4, pp. S26–S32, 2009. View at Google Scholar · View at Scopus
  18. C. Duftner, C. Goldberger, A. Falkenbach et al., “Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28- T cells in ankylosing spondylitis,” Arthritis Research & Therapy, vol. 5, no. 5, pp. R292–R300, 2003. View at Google Scholar · View at Scopus
  19. M. Schirmer, C. Goldberger, R. Würzner et al., “Circulating cytotoxic CD8(+) CD28(-) T cells in ankylosing spondylitis,” Arthritis Research, vol. 4, no. 1, pp. 71–76, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Rudwaleit, S. Siegert, Z. Yin et al., “Low T cell production of TNFα and IFNγ in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism,” Annals of the Rheumatic Diseases, vol. 60, no. 1, pp. 36–42, 2001. View at Publisher · View at Google Scholar
  21. L. Banica, A. Besliu, G. Pistol et al., “Quantification and molecular characterization of regulatory T cells in connective tissue diseases,” Autoimmunity, vol. 42, no. 1, pp. 41–49, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. C. L. Langrish, Y. Chen, W. M. Blumenschein et al., “IL-23 drives a pathogenic T cell population that induces autoimmune inflammation,” Journal of Experimental Medicine, vol. 201, no. 2, pp. 233–240, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. C. A. Murphy, C. L. Langrish, Y. Chen et al., “Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation,” Journal of Experimental Medicine, vol. 198, no. 12, pp. 1951–1957, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Liu, A. L. Putnam, Z. Xu-yu et al., “CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells,” Journal of Experimental Medicine, vol. 203, no. 7, pp. 1701–1711, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Seddiki, B. Santner-Nanan, J. Martinson et al., “Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells,” Journal of Experimental Medicine, vol. 203, no. 7, pp. 1693–1700, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Klein, C. C. Kretz, P. H. Krammer, and A. Kuhn, “CD127 (low/-) and FoxP3(+) expression levels characterize different regulatory T-cell populations in human peripheral blood,” Journal of Investigative Dermatology, vol. 130, no. 2, pp. 492–499, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Bossowski, M. Urban, and A. Stasiak-Barmuta, “Analysis of changes in the percentage of B (CD19) and T (CD3) lymphocytes, subsets CD4, CD8 and their memory (CD45RO), and naive (CD45RA) T cells in children with immune and non-immune thyroid diseases,” Journal of Pediatric Endocrinology and Metabolism, vol. 16, no. 1, pp. 63–70, 2003. View at Google Scholar · View at Scopus
  28. C. Dejaco, C. Duftner, A. Klauser, and M. Schirmer, “Altered T-cell subtypes in spondyloarthritis, rheumatoid arthritis and polymyalgia rheumatica,” Rheumatology International, vol. 30, no. 3, pp. 297–303, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Cauli, G. Dessole, M. T. Fiorillo et al., “Increased level of HLA-B27 expression in ankylosing spondylitis patients compared with healthy HLA-B27-positive subjects: a possible further susceptibility factor for the development of disease,” Rheumatology, vol. 41, no. 12, pp. 1375–1379, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Gratacos, A. Collado, X. Filella et al., “Serum cytokines (IL-6, TNF-α, IL-β and IFN-γ) in ankylosing spondylitis: a close correlation between serum IL-6 and disease activity and severity,” British Journal of Rheumatology, vol. 33, no. 10, pp. 927–931, 1994. View at Google Scholar · View at Scopus
  31. B. Sonel, H. Tutkak, and N. Düzgün, “Serum levels of IL-1beta, TNF-alpha, IL-8, and acute phase proteins in seronegative spondyloarthropathies,” Joint Bone Spine, vol. 69, no. 5, pp. 463–467, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. R. M. Aspalter, H. M. Wolf, and M. M. Eibl, “Chronic TNF-α exposure impairs TCR-signaling via TNF-RII but not TNF-RI,” Cellular Immunology, vol. 237, no. 1, pp. 55–67, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. L. D. Church, J. E. Goodall, D. A. Rider, P. A. Bacon, and S. P. Young, “Persistent TNF-α exposure impairs store operated calcium influx in CD4+ T lymphocytes,” FEBS Letters, vol. 579, no. 6, pp. 1539–1544, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. H.-T. Lee, W.-S. Chen, M.-H. Chen, C.-Y. Tsai, and C.-T. Chou, “The expression of proinflammatory cytokines and intracellular minerals in patients with ankylosing spondylitis,” Formosan Journal of Rheumatology, vol. 23, no. 1, pp. 40–46, 2009. View at Google Scholar
  35. G. Nagy, A. Koncz, and A. Perl, “T cell activation-induced mitochondrial hyperpolarization is mediated by Ca2+- and redox-dependent production of nitric oxide,” Journal of Immunology, vol. 171, no. 10, pp. 5188–5197, 2003. View at Google Scholar · View at Scopus
  36. G. Nagy, J. M. Clark, E. I. Buzás, C. L. Gorman, and A. P. Cope, “Nitric oxide, chronic inflammation and autoimmunity,” Immunology Letters, vol. 111, no. 1, pp. 1–5, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Ferret-Bernard, P. Saï, and J. M. Bach, “In vitro induction of inhibitory macrophage differentiation by granulocyte-macrophage colony-stimulating factor, stem cell factor and interferon-gamma from lineage phenotypes-negative c-kit-positive murine hematopoietic progenitor cells,” Immunology Letters, vol. 91, no. 2-3, pp. 221–227, 2004. View at Publisher · View at Google Scholar · View at Scopus