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Clinical and Developmental Immunology
Volume 2013, Article ID 164982, 6 pages
http://dx.doi.org/10.1155/2013/164982
Research Article

Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease: An Immunohistochemical Investigation

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan

Received 1 February 2013; Accepted 14 March 2013

Academic Editor: Giacomina Brunetti

Copyright © 2013 Taku Fujimura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Lloyd and A. M. Flanagan, “Mammary and extramammary Paget's disease,” Journal of Clinical Pathology, vol. 53, no. 10, pp. 742–749, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Shiomi, T. Noguchi, H. Nakayama et al., “Clinicopathological study of invasive extramammary Paget's disease: subgroup comparison according to invasion depth,” Journal of the European Academy of Dermatology and Venereology, 2012. View at Publisher · View at Google Scholar
  3. D. Heymann, B. Ory, F. Gouin, J. R. Green, and F. Rédini, “Bisphosphonates: new therapeutic agents for the treatment of bone tumors,” Trends in Molecular Medicine, vol. 10, no. 7, pp. 337–343, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. S. P. Jagdev, R. E. Coleman, C. M. Shipman, A. Rostami-H. A., and P. I. Croucher, “The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel,” British Journal of Cancer, vol. 84, no. 8, pp. 1126–1134, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Fehm, M. Zwirner, D. Wallwiener, H. Seeger, and H. Neubauer, “Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay,” BMC Cancer, vol. 12, article 308, 2012. View at Google Scholar
  6. C. Melani, S. Sangaletti, F. M. Barazzetta, Z. Werb, and M. P. Colombo, “Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma,” Cancer Research, vol. 67, no. 23, pp. 11438–11446, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Fujimura, Y. Kambayashi, T. Hidaka, A. Hashimoto, T. Haga, and S. Aiba, “Comparison of Foxp3+ regulatory T-cells and CD163+ macrophages in invasive and non-invasive extramammary Paget’s disease,” Acta Dermato-Venereologica, vol. 92, pp. 625–628, 2012. View at Google Scholar
  8. J. Gadiot, A. I. Hooijkaas, A. D. M. Kaiser, H. Van Tinteren, H. Van Boven, and C. Blank, “Overall survival and PD-L1 expression in metastasized malignant melanoma,” Cancer, vol. 117, no. 10, pp. 2192–2201, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Kambayashi, T. Fujimura, and S. Aiba, “Comparison of immunosuppressive cells and immunomodulatory cells in kerartoacanthoma and invasive squamous cell carcinoma,” Acta Dermato-Venereologica. In press.
  10. T. Fujimura, K. Mahnke, and A. H. Enk, “Myeloid derived suppressor cells and their role in tolerance inuction in cancer,” Journal of Dermatological Science, vol. 59, pp. 1–6, 2010. View at Google Scholar
  11. M. M. Tiemessen, A. L. Jagger, H. G. Evans, M. J. C. Van Herwijnen, S. John, and L. S. Taams, “CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 49, pp. 19446–19451, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Fujimura, S. Ring, V. Umansky, K. Mahnke, and A. H. Enk, “Regulatory T cells (Treg) stimulate B7-H1 expression in myeloid derived suppressor cells (MDSC) in ret melanomas,” Journal of Investigative Dermatology, vol. 132, pp. 1239–1246, 2012. View at Google Scholar
  13. T. Satoh, O. Takeuchi, A. Vandenbon et al., “The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection,” Nature Immunology, vol. 11, no. 10, pp. 936–944, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Heissig, K. Hattori, S. Dias et al., “Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of Kit-ligand,” Cell, vol. 109, no. 5, pp. 625–637, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. P. P. Vihinen, M. Hernberg, M. S. Vuoristo et al., “A phase II trial of bevacizumab with dacarbazine and daily low-dose interferon-α2a as first line treatment in metastatic melanoma,” Melanoma Research, vol. 20, no. 4, pp. 318–325, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Zhang, X. Luo, E. Sumithran et al., “Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression,” Oncogene, vol. 25, no. 55, pp. 7260–7266, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Monhian, B. S. Jewett, S. R. Baker, and J. Varani, “Matrix metalloproteinase expression in normal skin associated with basal cell carcinoma and in distal skin from the same patients,” Archives of Facial Plastic Surgery, vol. 7, no. 4, pp. 238–243, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Rasheed, M. M. Tolba Fawzi, M. R. E. Abdel-Halim, A. M. Eissa, N. Mohammed Salem, and S. Mahfouz, “Immunohistochemical study of the expression of matrix metalloproteinase-9 in skin lesions of mycosis fungoides,” American Journal of Dermatopathology, vol. 32, no. 2, pp. 162–169, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Ishibashi, T. Fujimura, A. Hashimoto et al., “Successful treatment of MMP9-expressing angiosarcoma with low-dose docetaxel and biphosphonate,” Case Reports in Dermatology, vol. 4, no. 1, pp. 5–9, 2012. View at Publisher · View at Google Scholar
  20. J. S. Pettersen, J. Fuentes-Duculan, M. Suárez-Fariñas et al., “Tumor-associated macrophages in the cutaneous SCC microenvironment are heterogeneously activated,” Journal of Investigative Dermatology, vol. 131, pp. 1322–1330, 2011. View at Google Scholar