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Clinical and Developmental Immunology
Volume 2013, Article ID 413928, 10 pages
http://dx.doi.org/10.1155/2013/413928
Research Article

Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation

1Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan
2Liver Transplantation Program, Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan
3Division of Transplant Immunology, Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan
4Iwao Hospital, 3059-1 Kawakami, Yufu, Oita 879-5102, Japan
5Department of Veterinary Medicine, National Pingtung University of Science & Technology, 1 Shuehfu Road, Neipu, Pingtung 912, Taiwan

Received 30 July 2013; Revised 31 October 2013; Accepted 13 November 2013

Academic Editor: Uner Kayabas

Copyright © 2013 Toshiaki Nakano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Erhardt and G. Tiegs, “Tolerance induction in response to liver inflammation,” Digestive Diseases, vol. 28, no. 1, pp. 86–92, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J. P. Böttcher, P. A. Knolle, and D. Stabenow, “Mechanisms balancing tolerance and immunity in the liver,” Digestive Diseases, vol. 29, no. 4, pp. 384–390, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. D. G. Doherty and C. O'Farrelly, “Lymphocyte repertoires in healthy liver,” in Liver Immunology, M. E. Gershwin, J. M. Vierling, and M. P. Manns, Eds., pp. 31–46, Hanley & Belfus, Philadelphia, Pa, USA, 2003. View at Google Scholar
  4. P. B. Medawar, “The immunology of transplantation,” Harvey Lectures, no. 52, pp. 144–176, 1956. View at Google Scholar · View at Scopus
  5. N. Kamada, H. S. Davies, and B. Roser, “Reversal of transplantation immunity by liver grafting,” Nature, vol. 292, no. 5826, pp. 840–842, 1981. View at Google Scholar · View at Scopus
  6. N. Kamada, G. Brons, and H. S. Davies, “Fully allogeneic liver grafting in rats induces a state of systemic nonreactivity to donor transplantation antigens,” Transplantation, vol. 29, no. 5, pp. 429–431, 1980. View at Google Scholar · View at Scopus
  7. N. Kamada, H. F. S. Davies, and D. Wight, “Liver transplantation in the rat: biochemical and histological evidence of complete tolerance induction in non-rejector strains,” Transplantation, vol. 35, no. 4, pp. 304–311, 1983. View at Google Scholar · View at Scopus
  8. W. Andrzejewski and C. Brolsch, “Postoperative reactions of rats after orthotopic liver transplantation: a model for the human response? A histological and biochemical study,” European Surgical Research, vol. 14, no. 6, pp. 428–439, 1982. View at Google Scholar · View at Scopus
  9. J. Sun, G. W. McCaughan, Y. Matsumoto, A. G. R. Sheil, N. D. Gallagher, and G. A. Bishop, “Tolerance to rat liver allografts: I. Differences between tolerance and rejection are more marked in the B cell compared with the T cell or cytokine response,” Transplantation, vol. 57, no. 9, pp. 1349–1357, 1994. View at Google Scholar · View at Scopus
  10. S. Goto, Y. Lin, C. Lai et al., “Telomerase activity in rat liver allografts,” Transplantation, vol. 69, no. 5, pp. 1013–1015, 2000. View at Google Scholar · View at Scopus
  11. T. Nakano, S. Kawamoto, C. Lai et al., “Liver transplatation-induced antihistone H1 autoantibodies suppress mixed lymphocyte reaction,” Transplantation, vol. 77, no. 10, pp. 1595–1603, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Nakano, S. Kawamoto, C.-Y. Lai et al., “Characterization of immunosuppressive factors expressed in serum by rat tolerogenic liver transplantation,” Transplantation Proceedings, vol. 37, no. 1, pp. 80–81, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Nakano, C.-Y. Lai, S. Goto et al., “Role of Antinuclear Antibodies in Experimental and Clinical Liver Transplantation,” Transplantation Proceedings, vol. 38, no. 10, pp. 3605–3606, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Nakano, S. Goto, C. Lai et al., “Experimental and clinical significance of antinuclear antibodies in liver transplantation,” Transplantation, vol. 83, no. 8, pp. 1122–1125, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Nakano, K. Ono, S. Goto et al., “Histone H1 Vaccine Therapy for Overcoming Acute Rejection in Experimental Organ Transplantation,” Transplantation Proceedings, vol. 38, no. 10, pp. 3247–3248, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Nakano, S. Goto, C. Lai et al., “Impact of vaccine therapy using nuclear histone H1 on allograft survival in experimental organ transplantation,” Transplant Immunology, vol. 17, no. 3, pp. 147–152, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Nakano, S. Goto, C. Lai et al., “Involvement of autoimmunity against nuclear histone H1 in liver transplantation tolerance,” Transplant Immunology, vol. 19, no. 2, pp. 87–92, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Nakano, S. Goto, C. Lai et al., “Immunological aspects and therapeutic significance of an autoantibody against histone H1 in a rat model of concanavalin A-induced hepatitis,” Immunology, vol. 129, no. 4, pp. 547–555, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. M. G. Peters, “Animal models of autoimmune liver disease,” Immunology and Cell Biology, vol. 80, no. 1, pp. 113–116, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Richter, E. Grabhorn, K. Helmke, M. P. Manns, R. Ganschow, and M. Burdelski, “Clinical relevance of autoantibodies after pediatric liver transplantation,” Clinical Transplantation, vol. 21, no. 3, pp. 427–432, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Kerkar, N. Hadzic, E. T. Davies et al., “De-novo autoimmune hepatitis after liver transplantation,” The Lancet, vol. 351, no. 9100, pp. 409–413, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Liberal, M. S. Longhi, C. R. Grant, G. Mieli-Vergani, and D. Vergani, “Autoimmune Hepatitis After Liver Transplantation,” Clinical Gastroenterology and Hepatology, vol. 10, no. 4, pp. 346–353, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Kamada and R. Y. Calne, “Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage,” Transplantation, vol. 28, no. 1, pp. 47–50, 1979. View at Google Scholar · View at Scopus
  24. R. Batey, Q. Cao, G. Pang, and R. L. Clancy, “Effects of CH-100, a chinese herbal medicine, on acute concanavalin A-mediated hepatitis in control and alcohol-fed rats,” Alcoholism, Clinical and Experimental Research, vol. 24, no. 6, pp. 852–858, 2000. View at Publisher · View at Google Scholar
  25. T. Nakano, C. L. Chen, and S. Goto, “Nuclear antigens and auto/alloantibody responses: friend or foe in transplant immunology,” Clinical & Developmental Immunology, vol. 2013, Article ID 267156, 9 pages, 2013. View at Publisher · View at Google Scholar
  26. K. Minami, K. Murata, C.-Y. Lee et al., “C4d deposition and clearance in cardiac transplants correlates with alloantibody levels and rejection in rats,” American Journal of Transplantation, vol. 6, no. 5, pp. 923–932, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Wang, O. Bloom, M. Zhang et al., “HMG-1 as a late mediator of endotoxin lethality in mice,” Science, vol. 285, no. 5425, pp. 248–251, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. M. T. Lotze and K. J. Tracey, “High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal,” Nature Reviews Immunology, vol. 5, no. 4, pp. 331–342, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. R. R. Zhou, H. B. Liu, J. P. Peng et al., “High mobility group box chromosomal protein 1 in acute-on-chronic liver failure patients and mice with ConA-induced acute liver injury,” Experimental and Molecular Pathology, vol. 93, no. 2, pp. 213–219, 2012. View at Publisher · View at Google Scholar
  30. L. W. Hsu, C. L. Chen, T. Nakano et al., “The role of a nuclear protein, histone H1, on signalling pathways for the maturation of dendritic cells,” Clinical and Experimental Immunology, vol. 152, no. 3, pp. 576–584, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Rovere-Querini, A. Capobianco, P. Scaffidi et al., “HMGB1 is an endogenous immune adjuvant released by necrotic cells,” EMBO Reports, vol. 5, no. 8, pp. 825–830, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Allam, C. R. Scherbaum, M. N. Darisipudi et al., “Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4,” Journal of the American Society of Nephrology, vol. 23, no. 8, pp. 1375–1388, 2012. View at Publisher · View at Google Scholar
  33. T. Li, J. M. Zhao, Y. Zhang et al., “Suppression of acute rejective response following orthotopic liver transplantation in experimental rats infected with echinococcus multilocularis,” Chinese Medical Journal, vol. 124, no. 18, pp. 2818–2823, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Nakano, C. Y. Lai, S. Goto et al., “Immunological and regenerative aspects of hepatic mast cells in liver allograft rejection and tolerance,” PLoS ONE, vol. 7, no. 5, Article ID e37202, 2012. View at Google Scholar
  35. I. Hilgert, V. Horejsi, P. Angelisova, and H. Kristofova, “Lentil lectin effectively induces allotransplantation tolerance in mice,” Nature, vol. 284, no. 5753, pp. 273–275, 1980. View at Google Scholar · View at Scopus
  36. R. G. Kinsky, J. Witkowski, M. Lehmann, and I. Hilgert, “Modification of suppressor/cytotoxic and helper subsets in lentil lectin-pretreated mice,” Immunology Letters, vol. 13, no. 1-2, pp. 51–53, 1986. View at Google Scholar · View at Scopus
  37. B. M. Wimer, “Immunosuppressive applications of PHA and other plant mitogens,” Cancer Biotherapy and Radiopharmaceuticals, vol. 13, no. 2, pp. 99–107, 1998. View at Google Scholar · View at Scopus
  38. A. Erhardt, M. Biburger, T. Papadopoulos, and G. Tiegs, “IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice,” Hepatology, vol. 45, no. 2, pp. 475–485, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. F. Ye, S. Yan, L. Xu et al., “Tr1 regulatory T cells induced by ConA pretreatment prevent mice from ConA-induced hepatitis,” Immunology Letters, vol. 122, no. 2, pp. 198–207, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. Y. Takaoka, S. Kawamoto, A. Katayama et al., “Unexpected T cell regulatory activity of anti-histone H1 autoantibody: its mode of action in regulatory T cell-dependent and -independent manners,” Biochemical and Biophysical Research Communications, vol. 431, no. 2, pp. 246–252, 2013. View at Google Scholar
  41. Y. Fujii, H. Kawamura, T. Kawamura et al., “Co-appearance of autoantibody-producing B220low B cells with NKT cells in the course of hepatic injury,” Cellular Immunology, vol. 260, no. 2, pp. 105–112, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Chhabra, K. Schlegel, M. D. Okusa, P. I. Lobo, and K. L. Brayman, “Naturally occurring immunoglobulin M, (nIgM) autoantibodies prevent autoimmune diabetes and mitigate inflammation after transplantation,” Annals of Surgery, vol. 256, no. 4, pp. 634–641, 2012. View at Google Scholar
  43. D. F. Barbeiro, H. V. Barbeiro, J. Faintuch et al., “B-1 cells temper endotoxemic inflammatory responses,” Immunobiology, vol. 216, no. 3, pp. 302–308, 2011. View at Publisher · View at Google Scholar · View at Scopus