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Clinical and Developmental Immunology
Volume 2013, Article ID 545621, 7 pages
http://dx.doi.org/10.1155/2013/545621
Review Article

New Allogeneic Hematopoietic Stem Cell Transplantation Method: Hematopoietic Stem Cell Transplantation Plus Thymus Transplantation for Intractable Diseases

1Department of Pathology, Kansai Medical University Kori Hospital, 8-45 Korihondori, Neyagawa, Osaka 572-8851, Japan
2Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, 2-5-1 Shinmachi, Hirakata City, Osaka 573-1010, Japan

Received 9 January 2013; Revised 17 March 2013; Accepted 19 April 2013

Academic Editor: Margaret G. Petroff

Copyright © 2013 Naoki Hosaka. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. D. Thomas, “Landmarks in the development of hematopoietic cell transplantation,” World Journal of Surgery, vol. 24, no. 7, pp. 815–818, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Bacigalupo, R. Oneto, B. Bruno et al., “Current results of bone marrow transplantation in patients with acquired severe aplastic anemia. Report of the European Group for Blood and Marrow transplantation. On behalf of the Working Party on Severe Aplastic Anemia of the European Group for Blood and Marrow Transplantation,” Acta Haematologica, vol. 103, pp. 19–25, 2000. View at Google Scholar
  3. R. L. Chen, J. W. Hou, P. Y. Chang, F. J. Tsai, and P. J. Wang, “Matched unrelated bone marrow transplantation without splenectomy for a child with Gaucher disease caused by homozygosity of the L444P mutation, who also suffered from schizencephaly,” Journal of Pediatric Hematology/Oncology, vol. 29, no. 1, pp. 57–59, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Sato, R. Kobayashi, N. Toita et al., “Stem cell transplantation in primary immunodeficiency disease patients,” Journal of Pediatric Hematology/Oncology, vol. 29, pp. 57–59, 2007. View at Google Scholar
  5. H. Kanamori, M. Tanaka, H. Kawaguchi et al., “Resolution of psoriasis following allogeneic bone marrow transplantation for chronic myelogenous leukemia: case report and review of the literature,” American Journal of Hematology, vol. 71, no. 1, pp. 41–44, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Saba and T. Flaig, “Bone marrow transplantation for nonmalignant diseases,” Journal of Hematotherapy and Stem Cell Research, vol. 11, no. 2, pp. 377–387, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. N. T. Ueno, J. D. Rizzo, T. Demirer et al., “Allogeneic hematopoietic cell transplantation for metastatic breast cancer,” Bone Marrow Transplantation, vol. 41, no. 6, pp. 537–545, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. N. J. Chao, “Graft-versus-host disease: the viewpoint from the donor T cell,” Biology of Blood and Marrow Transplantation, vol. 3, no. 1, pp. 1–10, 1997. View at Google Scholar · View at Scopus
  9. H. G. Klingemann, R. Storb, and A. Fefer, “Bone marrow transplantation in patients aged 45 years and older,” Blood, vol. 67, no. 3, pp. 770–776, 1986. View at Google Scholar · View at Scopus
  10. O. Ringdén, T. Paulin, B. Lönnqvist, and B. Nilsson, “An analysis of factors predisposing to chronic graft-versus-host disease,” Experimental Hematology, vol. 13, pp. 1062–1067, 1985. View at Google Scholar
  11. R. S. Weiner, M. M. Bortin, and R. P. Gale, “Interstitial pneumonitis after bone marrow transplantation. Assessment of risk factors,” Annals of Internal Medicine, vol. 104, no. 2, pp. 168–175, 1986. View at Google Scholar · View at Scopus
  12. H. Nagayama, J. Ooi, A. Tomonari et al., “Severe immune dysfunction after lethal neutron irradiation in a JCO nuclear facility accident victim,” International Journal of Hematology, vol. 76, no. 2, pp. 157–164, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Nagayama, K. Misawa, H. Tanaka et al., “Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim,” Bone Marrow Transplantation, vol. 29, no. 3, pp. 197–204, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Arzt, D. Kovalovsky, L. Müller Igaz et al., “Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action,” Annals of the New York Academy of Sciences, vol. 917, pp. 672–677, 2000. View at Google Scholar · View at Scopus
  15. M. L. Markert, A. Boeck, L. P. Hale et al., “Transplantation of thymus tissue in complete DiGeorge syndrome,” New England Journal of Medicine, vol. 341, no. 16, pp. 1180–1189, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. M. L. Markert, C. B. Hicks, J. A. Bartlett et al., “Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection,” AIDS Research and Human Retroviruses, vol. 16, no. 5, pp. 403–413, 2000. View at Google Scholar · View at Scopus
  17. H. Iwai and M. Inaba, “Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4+ T cells,” Journal of Neuroimmunology, vol. 250, pp. 1–8, 2012. View at Publisher · View at Google Scholar
  18. T. Miyake, N. Hosaka, W. Cui et al., “Adult thymus transplantation with allogeneic intra-bone marrow-bone marrow transplantation from same donor induces high thymopoiesis, mild graft-versus-host reaction and strong graft-versus-tumour effects,” Immunology, vol. 126, no. 4, pp. 552–564, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Hosaka, T. Ryu, T. Miyake et al., “Treatment of autoimmune diseases in MRL/lpr mice by allogenic bone marrow transplantation plus adult thymus transplantation,” Clinical and Experimental Immunology, vol. 147, no. 3, pp. 555–563, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Hosaka, M. Nose, M. Kyogoku et al., “Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+ mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 16, pp. 8558–8562, 1996. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Hosaka, W. Cui, Y. Zhang, T. Takaki, M. Inaba, and S. Ikehara, “Prolonged survival in mice with advanced tumors treated with syngeneic or allogeneic intra-bone marrow-bone marrow transplantation plus fetal thymus transplantation,” Cancer Immunology, Immunotherapy, vol. 59, no. 7, pp. 1121–1130, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Zhang, N. Hosaka, Y. Cui, M. Shi, M. Li, Q. Li et al., “Effects of intrabone marrow-bone marrow transplantation plus adult thymus transplantation on survival of mice bearing leukemia,” Stem Cells and Development, vol. 21, pp. 1441–1448, 2012. View at Google Scholar
  23. W. Cui, N. Hosaka, T. Miyake et al., “Analysis of tolerance induction using triple chimeric mice: major histocompatibility complex-disparate thymus, hemopoietic cells, and microenvironment,” Transplantation, vol. 85, no. 8, pp. 1151–1158, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Nishida, N. Hosaka, T. Takaki et al., “Allogeneic intra-BM-BMT plus adult thymus transplantation from same donor has benefits for long-term survival even after sublethal irradiation or low-dose BM cell injection,” Bone Marrow Transplantation, vol. 43, no. 11, pp. 829–837, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Ryu, N. Hosaka, T. Miyake et al., “Transplantation of newborn thymus plus hematopoietic stem cells can rescue supralethally irradiated mice,” Bone Marrow Transplantation, vol. 41, no. 7, pp. 659–666, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Li, N. G. Abraham, L. Vanella et al., “Successful modulation of type 2 diabetes in db/db mice with intra-bone marrow-bone marrow transplantation plus concurrent thymic transplantation,” Journal of Autoimmunity, vol. 35, no. 4, pp. 414–423, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Zhang, N. Hosaka, Y. Cui, M. Shi, and S. Ikehara, “Effects of allogeneic hematopoietic stem cell transplantation plus thymus transplantation on malignant tumors: comparison between fetal, newborn, and adult mice,” Stem Cells and Development, vol. 20, no. 4, pp. 599–607, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Hoffmann, J. Ermann, M. Edinger, C. Garrison Fathman, and S. Strober, “Donor-type CD4+CD25+ regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation,” Journal of Experimental Medicine, vol. 196, no. 3, pp. 389–399, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Z. Josefowicz, L. F. Lu, and A. Y. Rudensky, “Regulatory T cells: mechanisms of differentiation and function,” Annual Review of Immunology, vol. 30, pp. 531–564, 2012. View at Publisher · View at Google Scholar
  30. A. K. Abbas, A. H. Lichtman, and S. Pillai, “Lymphocyte development the rearrangement and expression of antigen receptor genes,” in Matulation of T Lymphocytes, W. Schmitt and R. Gruliow, Eds., pp. 175–188, Saunders Elsevier, Philadelphia, Pa, USA, 6th edition, 2009. View at Google Scholar
  31. B. Andrews, R. A. Eisenberg, and A. N. Theofilopoulos, “Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains,” Journal of Experimental Medicine, vol. 148, no. 5, pp. 1198–1215, 1978. View at Google Scholar · View at Scopus
  32. R. Watanabe-Fukunaga, C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata, “Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis,” Nature, vol. 356, no. 6367, pp. 314–317, 1992. View at Publisher · View at Google Scholar · View at Scopus
  33. E. A. Reap, K. Roof, K. Maynor, M. Borrero, J. Booker, and P. L. Cohen, “Radiation and stress-induced apoptosis: a role for fas/fas ligand interactions,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 11, pp. 5750–5755, 1997. View at Publisher · View at Google Scholar · View at Scopus
  34. J. K. Booker, E. A. Reap, and P. L. Cohen, “Expression and function of Fas on cells damaged by γ-irradiation in B6 and B6/lpr mice,” Journal of Immunology, vol. 161, no. 9, pp. 4536–4541, 1998. View at Google Scholar · View at Scopus
  35. H. Kanno, M. Nose, J. Itoh, Y. Taniguchi, and M. Kyogoku, “Spontaneous development of pancreatitis in the MRL/Mp strain of mice in autoimmune mechanism,” Clinical and Experimental Immunology, vol. 89, no. 1, pp. 68–73, 1992. View at Google Scholar · View at Scopus
  36. S. Ikehara, “Bone marrow transplantation for autoimmune diseases,” Acta Haematologica, vol. 99, no. 3, pp. 116–132, 1998. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Ikehara, “Autoimmune diseases as stem cell disorders: normal stem cell transplant for their treatment,” International journal of molecular medicine, vol. 1, no. 1, pp. 5–16, 1998. View at Google Scholar · View at Scopus
  38. T. Toge, M. Oride, E. Yanagawa, S. Hamamoto, H. Kohno, K. Nakanishi et al., “Prognostic significance of lymphocyte proliferative responses to mitogens in gastric cancer patients,” in Japanese Journal of Surgery, vol. 12, pp. 424–428, 1982. View at Google Scholar
  39. D. Mandal, A. Bhattacharyya, L. Lahiry, T. Choudhuri, G. Sa, and T. Das, “Failure in peripheral immuno-surveillance due to thymic atrophy: importance of thymocyte maturation and apoptosis in adult tumor-bearer,” Life Sciences, vol. 77, no. 21, pp. 2703–2716, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. T. Takeda, M. Hosokawa, and S. Takeshita, “A new murine model of accelerated senescence,” Mechanisms of Ageing and Development, vol. 17, no. 2, pp. 183–194, 1981. View at Publisher · View at Google Scholar · View at Scopus
  41. I. K. Chinn and M. L. Markert, “Induction of tolerance to parental parathyroid grafts using allogeneic thymus tissue in patients with DiGeorge anomaly,” Journal of Allergy and Clinical Immunology, vol. 127, no. 6, pp. 1351–1355, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. J. P. Després and I. Lemieux, “Abdominal obesity and metabolic syndrome,” Nature, vol. 444, no. 7121, pp. 881–887, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. T. Suganami, J. Nishida, and Y. Ogawa, “A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor α,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 10, pp. 2062–2068, 2005. View at Publisher · View at Google Scholar · View at Scopus
  44. R. L. Leibel, W. K. Chung, and S. C. Chua, “The molecular genetics of rodent single gene obesities,” Journal of Biological Chemistry, vol. 272, no. 51, pp. 31937–31940, 1997. View at Publisher · View at Google Scholar · View at Scopus
  45. G. Marodon, S. Fisson, B. Levacher, M. Fabre, B. L. Salomon, and D. Klatzmann, “Induction of antigen-specific tolerance by intrathymic injection of lentiviral vectors,” Blood, vol. 108, no. 9, pp. 2972–2978, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. G. Gottrand, K. Taleb, I. Ragon, A. S. Bergot, J. D. Goldstein, and G. Marodon, “Intrathymic injection of lentiviral vector curtails the immune response in the periphery of normal mice,” in Journal of Gene Medicine, vol. 14, pp. 90–99, 2012. View at Google Scholar
  47. N. Watanabe, Y. H. Wang, H. K. Lee et al., “Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus,” Nature, vol. 436, no. 7054, pp. 1181–1185, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. K. Aschenbrenner, L. M. D'Cruz, E. H. Vollmann et al., “Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells,” Nature Immunology, vol. 8, no. 4, pp. 351–358, 2007. View at Publisher · View at Google Scholar · View at Scopus
  49. A. Coutinho, I. Caramalho, E. Seixas, and J. Demengeot, “Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection,” Current Topics in Microbiology and Immunology, vol. 293, pp. 43–71, 2005. View at Google Scholar · View at Scopus
  50. S. Sakaguchi, M. Ono, R. Setoguchi et al., “Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease,” Immunological Reviews, vol. 212, pp. 8–27, 2006. View at Publisher · View at Google Scholar · View at Scopus
  51. H. Bour-Jordan and J. A. Bluestone, “Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells,” Immunological Reviews, vol. 229, no. 1, pp. 41–66, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. L. Zhang, L. Sun, and Y. Zhao, “Thymic epithelial progenitor cells and thymus regeneration: an update,” Cell Research, vol. 17, no. 1, pp. 50–55, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. L. Lai and J. Jin, “Generation of thymic epithelial cell progenitors by mouse embryonic stem cells,” Stem Cells, vol. 27, no. 12, pp. 3012–3020, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. T. Takaki, N. Hosaka, T. Miyake et al., “Presence of donor-derived thymic epithelial cells in [B6→MRL/lpr] mice after allogeneic intra-bone marrow-bone marrow transplantation (IBM-BMT),” Journal of Autoimmunity, vol. 31, no. 4, pp. 408–415, 2008. View at Publisher · View at Google Scholar · View at Scopus
  55. S. W. Rossi, W. E. Jenkinson, G. Anderson, and E. J. Jenkinson, “Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium,” Nature, vol. 441, no. 7096, pp. 988–991, 2006. View at Publisher · View at Google Scholar · View at Scopus
  56. L. Lai, C. Cui, J. Jin, Z. Hao, Q. Zheng, M. Ying et al., “Mouse embryonic stem cell-derived thymic epithelial cell progenitors enhance T-cell reconstitution after allogeneic bone marrow transplantation,” in Blood, vol. 118, pp. 3410–3418, 2011. View at Google Scholar
  57. A. Isotani, H. Hatayama, K. Kaseda, M. Ikawa, and M. Okabe, “Formation of a thymus from rat ES cells in xenogeneic nude mouserat ES chimeras,” Genes to Cells, vol. 16, no. 4, pp. 397–405, 2011. View at Publisher · View at Google Scholar · View at Scopus