Table of Contents Author Guidelines Submit a Manuscript
Clinical and Developmental Immunology
Volume 2013, Article ID 626823, 10 pages
http://dx.doi.org/10.1155/2013/626823
Research Article

Comparing Effects of BK Virus Agnoprotein and Herpes Simplex-1 ICP47 on MHC-I and MHC-II Expression

1Transplantation & Clinical Virology, Department Biomedicine Haus Petersplatz, University of Basel, Petersplatz 10, CH-4003 Basel, Switzerland
2Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland

Received 13 December 2012; Accepted 30 January 2013

Academic Editor: Rossana Cavallo

Copyright © 2013 Michela Cioni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Kean, S. Rao, M. Wang, and R. L. Garcea, “Seroepidemiology of human polyomaviruses,” PLoS Pathogens, vol. 5, no. 3, Article ID e1000363, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. N. L. Nguyen, B. M. Le, and D. Wang, “Serologic evidence of frequent human infection with WU and KI polyomaviruses,” Emerging Infectious Diseases, vol. 15, no. 8, pp. 1199–1205, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Egli, L. Infanti, A. Dumoulin et al., “Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors,” Journal of Infectious Diseases, vol. 199, no. 6, pp. 837–846, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. R. M. Schowalter, D. V. Pastrana, K. A. Pumphrey, A. L. Moyer, and C. B. Buck, “Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin,” Cell Host and Microbe, vol. 7, no. 6, pp. 509–515, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. W. A. Knowles, “Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV),” Advances in Experimental Medicine and Biology, vol. 577, pp. 19–45, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Dalianis and H. H. Hirsch, “Human polyomaviruses in disease and cancer,” Virology, vol. 437, no. 2, pp. 63–72, 2013. View at Publisher · View at Google Scholar
  7. T. Dalianis, T. Ramqvist, K. Andreasson, J. M. Kean, and R. L. Garcea, “KI, WU and Merkel cell polyomaviruses: a new era for human polyomavirus research,” Seminars in Cancer Biology, vol. 19, no. 4, pp. 270–275, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. H. H. Hirsch, “Polyoma and papilloma virus infections after hematopoietic stem cell or solid organ transplantation,” in Transplant Infections, P. Bowden, P. Ljungman, and D. R. Snydman, Eds., pp. 465–482, Lippincott Williams & Wilkins, New York, NY, USA, 3rd edition, 2010. View at Google Scholar
  9. C. H. Rinaldo, T. Traavik, and A. Hey, “The agnogene of the human polyomavirus BK is expressed,” Journal of Virology, vol. 72, no. 7, pp. 6233–6236, 1998. View at Google Scholar · View at Scopus
  10. I. Akan, I. K. Sariyer, R. Biffi et al., “Human polyomavirus JCV late leader peptide region contains important regulatory elements,” Virology, vol. 349, no. 1, pp. 66–78, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. S. A. Sedman, P. J. Good, and J. E. Mertz, “Leader-encoded open reading frames modulate both the absolute and relative rates of synthesis of the virion proteins of simian virus 40,” Journal of Virology, vol. 63, no. 9, pp. 3884–3893, 1989. View at Google Scholar · View at Scopus
  12. K. Khalili, M. K. White, H. Sawa, K. Nagashima, and M. Safak, “The agnoprotein of polyomaviruses: a multifunctional auxiliary protein,” Journal of Cellular Physiology, vol. 204, no. 1, pp. 1–7, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Johannessen, M. Walquist, N. Gerits, M. Dragset, A. Spang, and U. Moens, “BKV agnoprotein interacts with alpha-soluble N-ethylmaleimide-sensitive fusion attachment protein, and negatively influences transport of VSVG-EGFP,” PLoS One, vol. 6, no. 9, Article ID e24489, 2011. View at Google Scholar
  14. T. Suzuki, Y. Orba, Y. Okada et al., “The human polyoma JC virus agnoprotein acts as a viroporin,” PLoS Pathogens, vol. 6, no. 3, Article ID e1000801, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Unterstab, R. Gosert, D. Leuenberger, P. Lorentz, C. H. Rinaldo, and H. H. Hirsch, “The polyomavirus BK agnoprotein co-localizes with lipid droplets,” Virology, vol. 399, no. 2, pp. 322–331, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Leuenberger, P. A. Andresen, R. Gosert et al., “Human polyomavirus type 1 (BK virus) agnoprotein is abundantly expressed but immunologically ignored,” Clinical and Vaccine Immunology, vol. 14, no. 8, pp. 959–968, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Bodaghi, P. Comoli, R. Bösch et al., “Antibody responses to recombinant polyomavirus BK large T and VP1 proteins in young kidney transplant patients,” Journal of Clinical Microbiology, vol. 47, no. 8, pp. 2577–2585, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Binggeli, A. Egli, S. Schaub et al., “Polyomavirus BK-specific cellular immune response to VP1 and large T-antigen in kidney transplant recipients,” American Journal of Transplantation, vol. 7, no. 5, pp. 1131–1139, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. V. Nickeleit, H. H. Hirsch, M. Zeiler et al., “BK-virus nephropathy in renal transplants—tubular necrosis, MHC-class II expression and rejection in a puzzling game,” Nephrology Dialysis Transplantation, vol. 15, no. 3, pp. 324–332, 2000. View at Google Scholar · View at Scopus
  20. D. Beinert, L. Neumann, S. Uebel, and R. Tampé, “Structure of the viral TAP-inhibitor ICP47 induced by membrane association,” Biochemistry, vol. 36, no. 15, pp. 4694–4700, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Aisenbrey, C. Sizun, J. Koch et al., “Structure and dynamics of membrane-associated ICP47, a viral inhibitor of the MHC I antigen-processing machinery,” Journal of Biological Chemistry, vol. 281, no. 41, pp. 30365–30372, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Galocha, A. Hill, B. C. Barnett et al., “The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues,” Journal of Experimental Medicine, vol. 185, no. 9, pp. 1565–1572, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Englert, X. Hou, S. Maheswaran et al., “WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis,” The EMBO Journal, vol. 14, no. 19, pp. 4662–4675, 1995. View at Google Scholar · View at Scopus
  24. T. H. Hansen and M. Bouvier, “MHC class i antigen presentation: learning from viral evasion strategies,” Nature Reviews Immunology, vol. 9, no. 7, pp. 503–513, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. H. H. Hirsch, C. B. Drachenberg, J. Steiger, and E. Ramos, “Polyomavirus-associated nephropathy in renal transplantation: critical issues of screening and management,” Advances in Experimental Medicine and Biology, vol. 577, pp. 160–173, 2006. View at Publisher · View at Google Scholar · View at Scopus