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Clinical and Developmental Immunology
Volume 2013, Article ID 874514, 7 pages
http://dx.doi.org/10.1155/2013/874514
Research Article

Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection

1Department of Pathogenic Biology and Immunology, Southeast University Medical School, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China
2Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, China
3The Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210000, China
4Department of Epidemiology, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China

Received 15 July 2013; Revised 17 September 2013; Accepted 17 September 2013

Academic Editor: Saied Mirshahidi

Copyright © 2013 Ning Pan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. B. El-Serag, “Hepatocellular carcinoma,” The New England Journal of Medicine, vol. 365, no. 12, pp. 1118–1127, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. B. J. McMahon, L. Bulkow, A. Harpster et al., “Screening for hepatocellular carcinoma in Alaska natives infected with chronic hepatitis B: a 16-year population-based study,” Hepatology, vol. 32, no. 4 I, pp. 842–846, 2000. View at Google Scholar · View at Scopus
  3. B. Zhang, B. Yang, and Z. Tang, “Randomized controlled trial of screening for hepatocellular carcinoma,” Journal of Cancer Research and Clinical Oncology, vol. 130, no. 7, pp. 417–422, 2004. View at Google Scholar · View at Scopus
  4. D. Amarapurkar, K. Han, H. L. Chan, and Y. Ueno, “Application of surveillance programs for hepatocellular carcinoma in the Asia-Pacific Region,” Journal of Gastroenterology and Hepatology, vol. 24, no. 6, pp. 955–961, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Farrell, “Prevention of hepatocellular carcinoma in the Asia-Pacific region: consensus statements,” Journal of Gastroenterology and Hepatology, vol. 25, no. 4, pp. 657–663, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. Z. Tian, Y. Chen, and B. Gao, “Natural killer cells in liver disease,” Hepatology, vol. 57, no. 4, pp. 1654–1662, 2013. View at Google Scholar
  7. C. Dunn, M. Brunetto, G. Reynolds et al., “Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage,” Journal of Experimental Medicine, vol. 204, no. 3, pp. 667–680, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Chen, R. Sun, W. Jiang, H. Wei, and Z. Tian, “Liver-specific HBsAg transgenic mice are over-sensitive to Poly(I:C)-induced liver injury in NK cell- and IFN-γ-dependent manner,” Journal of Hepatology, vol. 47, no. 2, pp. 183–190, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Trachtenberg, M. Vinson, E. Hayes et al., “HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China,” Tissue Antigens, vol. 70, no. 6, pp. 455–463, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Mantovani, P. Allavena, A. Sica, and F. Balkwill, “Cancer-related inflammation,” Nature, vol. 454, no. 7203, pp. 436–444, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Berasain, J. Castillo, M. J. Perugorria, M. U. Latasa, J. Prieto, and M. A. Avila, “Inflammation and liver cancer: new molecular links,” Annals of the New York Academy of Sciences, vol. 1155, pp. 206–221, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. L. L. Lanier, “NK cell recognition,” Annual Review of Immunology, vol. 23, pp. 225–274, 2005. View at Google Scholar
  13. J. E. Gumperz, V. Litwin, J. H. Phillips, L. L. Lanier, and P. Parham, “The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor,” Journal of Experimental Medicine, vol. 181, no. 3, pp. 1133–1144, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Stern, L. Ruggeri, M. Capanni, A. Mancusi, and A. Velardi, “Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1,” Blood, vol. 112, no. 3, pp. 708–710, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. J. H. Chewning, C. N. Gudme, K. C. Hsu, A. Selvakumar, and B. Dupont, “KIR2DS1-positive NK cells mediate alloresponse against the C2 HLA-KIR ligand group in vitro,” Journal of Immunology, vol. 179, no. 2, pp. 854–868, 2007. View at Google Scholar · View at Scopus
  16. B. Foley, D. De Santis, L. Lathbury, F. Christiansen, and C. Witt, “KIR2DS1-mediated activation overrides NKG2A-mediated inhibition in HLA-C C2-negative individuals,” International Immunology, vol. 20, no. 4, pp. 555–563, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Hansasuta, T. Dong, H. Thananchai et al., “Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific,” European Journal of Immunology, vol. 34, no. 6, pp. 1673–1679, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Thielens, E. Vivier, and F. Romagné, “NK cell MHC class I specific receptors (KIR): from biology to clinical intervention,” Current Opinion in Immunology, vol. 24, no. 2, pp. 239–245, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Kusnierczyk, “Killer cell immunoglobulin-like receptor gene associations with autoimmune and allergic diseases, recurrent spontaneous abortion, and neoplasms,” Frontiers in Immunology, vol. 4, article 8, 2013. View at Google Scholar
  20. N. Pan, W. Jiang, H. Sun et al., “KIR and HLA loci are associated with hepatocellular carcinoma development in patients with hepatitis B virus infection: a case-control study,” PLoS ONE, vol. 6, no. 10, Article ID e25682, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Pan, K. Chen, J. Qiu et al., “Human leukocyte antigen class I alleles and haplotypes associated with primary hepatocellular carcinoma in persistent HBV-infected patients,” Human Immunology, vol. 74, no. 6, pp. 758–763, 2013. View at Google Scholar
  22. K. C. Hsu, X. Liu, A. Selvakumar, E. Mickelson, R. J. O'Reilly, and B. Dupont, “Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets,” Journal of Immunology, vol. 169, no. 9, pp. 5118–5129, 2002. View at Google Scholar · View at Scopus
  23. P. P. J. Dunn, S. T. Cox, and A. Little, “Sequencing protocols for detection of HLA class I polymorphism,” Methods in Molecular Biology, vol. 210, pp. 191–222, 2003. View at Google Scholar · View at Scopus
  24. W. Helmberg, R. Dunivin, and M. Feolo, “The sequencing-based typing tool of dbMHC: typing highly polymorphic gene sequences,” Nucleic Acids Research, vol. 32, pp. W173–W175, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. W. Jiang, J. Q. Zhang, N. Pan, J. H. Xu, and W. Xie, “Identification of a novel HLA-A allele, HLA-A*9216,” Tissue Antigens, vol. 71, no. 5, pp. 479–480, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. H. B. El-Serag and K. L. Rudolph, “Hepatocellular carcinoma: epidemiology and molecular carcinogenesis,” Gastroenterology, vol. 132, no. 7, pp. 2557–2576, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Gao, W. Yang, F. Bray et al., “Declining rates of hepatocellular carcinoma in urban Shanghai: incidence trends in 1976–2005,” European Journal of Epidemiology, vol. 27, no. 1, pp. 39–46, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. China MoHotPsRo, “Diagnosis, management, and treatment of hepatocellular carcinoma (v2011),” Journal of Clinical Hepatology, vol. 16, no. 10, pp. 1141–1159, 2011. View at Google Scholar
  29. E. C. Doo, J. H. Hoofnagle, and G. P. Rodgers, “NIH consensus development conference: management of hepatitis B. Introduction,” Hepatology, vol. 49, supplement, no. 5, pp. S1–S3, 2009. View at Google Scholar · View at Scopus
  30. J. Bruix and M. Sherman, “Management of hepatocellular carcinoma,” Hepatology, vol. 42, no. 5, pp. 1208–1236, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. H. A. Hong, A. S. Loubser, D. de Assis Rosa et al., “Killer-cell immunoglobulin-like receptor genotyping and HLA killer-cell immunoglobulin-like receptor-ligand identification by real-time polymerase chain reaction,” Tissue Antigens, vol. 78, no. 3, pp. 185–194, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. B. C. Taylor, J. Yuan, T. A. Shamliyan, A. Shaukat, R. L. Kane, and T. J. Wilt, “Clinical outcomes in adults with chronic hepatitis B in association with patient and viral characteristics: a systematic review of evidence,” Hepatology, vol. 49, supplement, no. 5, pp. S85–S95, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Chen, H. Yang, J. Su et al., “Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA Level,” Journal of the American Medical Association, vol. 295, no. 1, pp. 65–73, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. B. J. McMahon, P. Holck, L. Bulkow, and M. Snowball, “Serologic and clinical outcomes of 1536 Alaska natives chronically infected with hepatitis B virus,” Annals of Internal Medicine, vol. 135, no. 9, pp. 759–768, 2001. View at Google Scholar · View at Scopus
  35. H. L.-Y. Chan, A. Y. Hui, M. L. Wong et al., “Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma,” Gut, vol. 53, no. 10, pp. 1494–1498, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. S. E. Livingston, J. P. Simonetti, B. J. McMahon et al., “Hepatitis B virus genotypes in Alaska Native people with hepatocellular carcinoma: preponderance of genotype F,” Journal of Infectious Diseases, vol. 195, no. 1, pp. 5–11, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. M. J. Tong, L. M. Blatt, J. Kao, J. T. Cheng, and W. G. Corey, “Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen-positive hepatocellular carcinoma: a comparison with chronic carriers,” Liver International, vol. 27, no. 10, pp. 1356–1363, 2007. View at Publisher · View at Google Scholar · View at Scopus