Novel Clinical and Diagnostic Aspects of Antineutrophil Cytoplasmic Antibodies
Figure 1
Appearance of cytoplasmic indirect immunofluorescence pattern (C-ANCA, Figure 1(a)) and perinuclear (P-ANCA, Figure 1(b)) on ethanol-fixed human neutrophil cells. The C-ANCA pattern is largely caused by autoantibodies targeting serine protease proteinase-3 (PR3-ANCA), while the P-ANCA pattern is caused by antibodies binding to many antigens among which myeloperoxidase (MPO-ANCA) is the most frequent target in primary systemic vasculitis [11].
