Evaluation of Diagnostic Value in Using a Panel of Multiple Tumor-Associated Antigens for Immunodiagnosis of Cancer

Table 4

Summary of diagnostic value of antibodies to a panel of eight TAAs.

	Lung	HCC	Colorectal	Gastric	Others	Total	NHS
Any TAA positive	63 (A1)	33 (A2)	30 (A3)	23 (A4)	44 (A5)	193 (A6)	8 (B)
All TAA negative	35 (C1)	17 (C2)	16 (C3)	18 (C4)	25 (C5)	111 (C6)	50 (D)
Youden’s index	0.505	0.522	0.514	0.423	0.500	0.497	—
+Likelihood ratio	4.66	4.76	4.72	4.07	4.62	4.60	—
−Likelihood ratio	0.41	0.39	0.45	0.51	0.42	0.42	—
+Predictive value	88.7	80.5	78.9	74.2	84.6	96.0	—
−Predictive value	58.8	74.6	75.8	73.5	66.7	31.1	—
Agreement rate	72.4	76.9	76.9	73.7	74.0	67.1	—
Kappa value	0.46	0.53	0.52	0.44	0.49	0.51	—

Note: Calculation Formulas used in Table 4 were as follows.
Youden’s index = sensitivity + specificity − 1.
Positive (+) likelihood ratio = sensitivity/(1 – specificity).
Negative (−) likelihood ratio = (1 – sensitivity)/specificity.
Positive (+) predictive value = A/(A+B)×100%.
Negative (−) predictive value = D/(C+D)×100%.
Agreement rate = (A + D)/(A+B+C+D)×100%.
Kappavalue= [N(A+D)−(R₁C₁+R₂C₂)]/[N₂−(R₁C₁+R₂C₂)].