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Journal of Immunology Research
Volume 2015, Article ID 108451, 11 pages
Review Article

Bone-Immune Cell Crosstalk: Bone Diseases

1Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy
2Department of Medical Science, Section of Gerontology and Bone Metabolism Diseases, University of Torino, 10126 Torino, Italy
3Department of Orthopedics, Washington University School of Medicine, St. Louis, MO 63110, USA
4Department of Basic Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy

Received 17 October 2014; Revised 22 January 2015; Accepted 25 January 2015

Academic Editor: Chikao Morimoto

Copyright © 2015 Giorgio Mori et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incompletely understood. This review aims to shed new lights into the mechanisms of bone diseases involving immune cells. In particular, we focused our attention on the major pathogenic mechanism underlying periodontal disease, psoriatic arthritis, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, metastatic solid tumors, and multiple myeloma.