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Journal of Immunology Research
Volume 2015 (2015), Article ID 153132, 7 pages
http://dx.doi.org/10.1155/2015/153132
Research Article

Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL

1Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China and Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Peking University, Ministry of Education, Beijing 100034, China
2Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China

Received 21 April 2015; Revised 26 May 2015; Accepted 28 May 2015

Academic Editor: Fulvia Ceccarelli

Copyright © 2015 Yue-miao Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Alarcón-Segovia, M. E. Alarcón-Riquelme, M. H. Cardiel et al., “Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort,” Arthritis & Rheumatism, vol. 52, no. 4, pp. 1138–1147, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. O. J. Rullo and B. P. Tsao, “Recent insights into the genetic basis of systemic lupus erythematosus,” Annals of the Rheumatic Diseases, vol. 72, supplement 2, pp. ii56–ii61, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Vidal, M. E. Cusick, and A.-L. Barabási, “Interactome networks and human disease,” Cell, vol. 144, no. 6, pp. 986–998, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Sanyal, B. R. Lajoie, G. Jain, and J. Dekker, “The long-range interaction landscape of gene promoters,” Nature, vol. 489, no. 7414, pp. 109–113, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. B. E. Stranger, A. C. Nica, M. S. Forrest et al., “Population genomics of human gene expression,” Nature Genetics, vol. 39, no. 10, pp. 1217–1224, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. A. L. Dixon, L. Liang, M. F. Moffatt et al., “A genome-wide association study of global gene expression,” Nature Genetics, vol. 39, no. 10, pp. 1202–1207, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. W. Cookson, L. Liang, G. Abecasis, M. Moffatt, and M. Lathrop, “Mapping complex disease traits with global gene expression,” Nature Reviews Genetics, vol. 10, no. 3, pp. 184–194, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. J. B. Harley, M. E. Alarcón-Riquelme, L. A. Criswell et al., “Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci,” Nature Genetics, vol. 40, no. 2, pp. 204–210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. J. W. Han, H. F. Zheng, Y. Cui et al., “Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus,” Nature Genetics, vol. 41, no. 11, pp. 1234–1237, 2009. View at Publisher · View at Google Scholar
  10. B. Li, Y. Yue, C. Dong, Y. Shi, and S. Xiong, “Blockade of macrophage autophagy ameliorates activated lymphocytes-derived DNA induced murine lupus possibly via inhibition of proinflammatory cytokine production,” Clinical and Experimental Rheumatology, vol. 32, no. 5, pp. 705–714, 2014. View at Google Scholar
  11. X.-J. Zhou, X.-L. Lu, J.-C. Lv et al., “Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population,” Annals of the Rheumatic Diseases, vol. 70, no. 7, pp. 1330–1337, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Yvert, R. B. Brem, J. Whittle et al., “Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors,” Nature Genetics, vol. 35, no. 1, pp. 57–64, 2003. View at Google Scholar · View at Scopus
  13. V. G. Cheung, R. R. Nayak, I. X. Wang et al., “Polymorphic cis- and trans-regulation of human gene expression,” PLoS Biology, vol. 8, no. 9, Article ID e1000480, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. S. B. Montgomery and E. T. Dermitzakis, “From expression QTLs to personalized transcriptomics,” Nature Reviews Genetics, vol. 12, no. 4, pp. 277–282, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. E. M. Tan, A. S. Cohen, J. F. Fries et al., “The 1982 revised criteria for the classification of systemic lupus erythematosus,” Arthritis & Rheumatism, vol. 25, no. 11, pp. 1271–1277, 1982. View at Publisher · View at Google Scholar · View at Scopus
  16. X.-J. Zhou, S. K. Nath, Y.-Y. Qi et al., “Brief Report: identification of MTMR3 as a novel susceptibility gene for lupus nephritis in northern Han Chinese by shared-gene analysis with IgA nephropathy,” Arthritis & Rheumatology, vol. 66, no. 10, pp. 2842–2848, 2014. View at Publisher · View at Google Scholar
  17. J. Zhu, P. Y. Lum, J. Lamb et al., “An integrative genomics approach to the reconstruction of gene networks in segregating populations,” Cytogenetic and Genome Research, vol. 105, no. 2–4, pp. 363–374, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. I. J. McGough, F. Steinberg, M. Gallon et al., “Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling,” Journal of Cell Science, vol. 127, no. 22, pp. 4940–4953, 2014. View at Publisher · View at Google Scholar
  19. M. Arvio, K. Laiho, M. Kauppi et al., “Carriers of the aspartylglucosaminuria genetic mutation and chronic arthritis,” Annals of the Rheumatic Diseases, vol. 61, no. 2, pp. 180–181, 2002. View at Google Scholar · View at Scopus
  20. J. Gu, K. Li, M. Li et al., “A role for p21-activated kinase 7 in the development of gastric cancer,” FEBS Journal, vol. 280, no. 1, pp. 46–55, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Ko, Y. Huang, A. M. Jankowska et al., “Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2,” Nature, vol. 468, no. 7325, pp. 839–843, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Yamazaki, R. Taby, A. Vasanthakumar et al., “Efects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia,” Epigenetics, vol. 7, no. 2, pp. 201–207, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Y. Kim, E. Kwon, P. D. Hartley et al., “CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression,” Molecular Cell, vol. 49, no. 4, pp. 632–644, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. R. W. McMurray, “Adhesion molecules in autoimmune disease,” Seminars in Arthritis and Rheumatism, vol. 25, no. 4, pp. 215–233, 1996. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Lowin and R. H. Straub, “Integrins and their ligands in rheumatoid arthritis,” Arthritis Research and Therapy, vol. 13, no. 5, article 244, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Ghassibe-Sabbagh, M. Haber, A. K. Salloum et al., “T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility,” Scientific Reports, vol. 4, article 7351, 2014. View at Publisher · View at Google Scholar
  27. S. Israeli, Z. Khamaysi, D. Fuchs-Telem et al., “A mutation in LIPN, encoding epidermal lipase N, causes a late-onset form of autosomal-recessive congenital ichthyosis,” The American Journal of Human Genetics, vol. 88, no. 4, pp. 482–487, 2011. View at Publisher · View at Google Scholar · View at Scopus