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Journal of Immunology Research
Volume 2015, Article ID 254245, 6 pages
http://dx.doi.org/10.1155/2015/254245
Research Article

The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity

1Division of Allergy & Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, 4940 Haifa, Israel
2Rheumatology Unit, Bnai Zion Medical Center, Faculty of Medicine, Technion, 4940 Haifa, Israel
3B. Shine Rheumatology Unit, Rambam Health Care Campus, Faculty of Medicine, Technion, 4940 Haifa, Israel

Received 28 July 2015; Accepted 8 September 2015

Academic Editor: Carlo Perricone

Copyright © 2015 Zahava Vadasz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. M. Talaat, S. F. Mohamed, I. H. Bassyouni, and A. A. Raouf, “Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: correlation with disease activity,” Cytokine, vol. 72, no. 2, pp. 146–153, 2015 (Chinese). View at Publisher · View at Google Scholar · View at Scopus
  2. K. Shah, W.-W. Lee, S.-H. Lee et al., “Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus,” Arthritis Research & Therapy, vol. 12, no. 2, article R53, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Li, B. Guo, H. Wu, L. Tan, C. Chang, and Q. Lu, “Interleukin-17 in systemic lupus erythematosus: a comprehensive review,” Autoimmunity, vol. 48, no. 6, pp. 353–361, 2015. View at Publisher · View at Google Scholar
  4. B. Terrier, N. Costedoat-Chalumeau, M. Garrido et al., “Interleukin 21 correlates with T cell and B cell subset alterations in systemic lupus erythematosus,” The Journal of Rheumatology, vol. 39, no. 9, pp. 1819–1828, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Futatsugi-Yumikura, K. Matsushita, A. Fukuoka et al., “Pathogenic Th2-type follicular helper T cells contribute to the development of lupus in Fas-deficient mice,” International Immunology, vol. 26, no. 4, pp. 221–231, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Yan, S. Ye, G. Chen, M. Kuang, N. Shen, and S. Chen, “Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-α-producing antigen-presenting cells,” Arthritis and Rheumatism, vol. 58, no. 3, pp. 801–812, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Ray, L. Wang, and B. N. Dittel, “IL-10-independent regulatory B-cell subsets and mechanisms of action,” International Immunology, 2015. View at Publisher · View at Google Scholar
  8. P. A. Blair, L. Y. Noreña, F. Flores-Borja et al., “CD19+CD24hiCD38hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus,” Immunity, vol. 32, no. 1, pp. 129–140, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Kessel, T. Haj, R. Peri et al., “Human CD19+CD25high B regulatory cells suppress proliferation of CD4+ T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells,” Autoimmunity Reviews, vol. 11, no. 9, pp. 670–677, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Noh and G. Noh, “Allergen specific responses of CD19high and CD19low B cells in non-IgE mediated food allergy of late eczematous reactions in atopic dermatitis: presence of IL-17 and IL-32 producing regulatory B cells (Br17 & Br32),” Inflammation & Allergy-Drug Targets, vol. 11, no. 4, pp. 320–329, 2012. View at Google Scholar
  11. S. K. Lundy, “Killer B lymphocytes: the evidence and the potential,” Inflammation Research, vol. 58, no. 7, pp. 345–357, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Mion, S. Topnon, B. Toffoletto, D. Cesselli, C. E. Pucillo, and G. Vitale, “IL-10 production by B cells is differentially regulated by immune-mediated and infectious stimuli and requires p38 activation,” Molecular Immunology, vol. 62, no. 2, pp. 266–276, 2014. View at Publisher · View at Google Scholar
  13. K. Yanaba, J.-D. Bouaziz, T. Matsushita, T. Tsubata, and T. F. Tedder, “The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals,” Journal of Immunology, vol. 182, no. 12, pp. 7459–7472, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. Z. Vadasz, T. Haj, A. Balbir et al., “A regulatory role for CD72 expression on B cells in systemic lupus erythematosus,” Seminars in Arthritis & Rheumatism, vol. 43, no. 6, pp. 767–771, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. P. López, E. Alonso-Pérez, J. Rodríguez-Carrio, and A. Suárez, “Influence of Atg5 mutation in SLE depends on functional IL-10 genotype,” PLoS ONE, vol. 8, no. 10, Article ID e78756, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Bombardier, D. D. Gladman, M. B. Urovitz, D. Caron, and C. H. Chang, “Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE,” Arthritis and Rheumatism, vol. 35, no. 6, pp. 630–640, 1992. View at Publisher · View at Google Scholar
  17. B. Kigel, A. Varshavsky, O. Kessler, and G. Neufeld, “Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells,” PLoS ONE, vol. 3, no. 9, article e3287, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. J.-M. Berthelot, C. Jamin, K. Amrouche, B. Le Goff, Y. Maugars, and P. Youinou, “Regulatory B cells play a key role in immune system balance,” Joint Bone Spine, vol. 80, no. 1, pp. 18–22, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Iwata, T. Matsushita, M. Horikawa et al., “Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells,” Blood, vol. 117, no. 2, pp. 530–541, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Bonardelle, K. Benihoud, N. Kiger, and P. Bobé, “B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice,” Journal of Leukocyte Biology, vol. 78, no. 5, pp. 1052–1059, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. C. de Andrés, M. Tejera-Alhambra, B. Alonso et al., “New regulatory CD19+CD25+ B-cell subset in clinically isolated syndrome and multiple sclerosis relapse. Changes after glucocorticoids,” Journal of Neuroimmunology, vol. 270, no. 1-2, pp. 37–44, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Guo, X. Zhang, M. Qin, and X. Wang, “Changes in peripheral CD19+Foxp3+ and CD19+TGF-β+ regulatory B cell populations in rheumatoid arthritis patients with interstitial lung disease,” Journal of Thoracic Disease, vol. 7, no. 3, pp. 471–477, 2015. View at Publisher · View at Google Scholar
  23. Z. Sun, R. Zhang, H. Wang et al., “Serum IL-10 from systemic lupus erythematosus patients suppresses the differentiation and function of monocyte-derived dendritic cells,” Journal of Biomedical Research, vol. 26, no. 6, pp. 456–466, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Yang, B. Sun, H. Wang, C. Yin, X. Wang, and X. Ji, “Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling,” Journal of Biomedical Research, vol. 29, no. 3, pp. 232–240, 2015. View at Publisher · View at Google Scholar
  25. M. Yang, L. Sun, S. Wang et al., “Cutting edge: novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells,” The Journal of Immunology, vol. 184, no. 7, pp. 3321–3325, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Yehudai, A. Snir, R. Peri et al., “B cell-activating factor enhances interleukin-6 and interleukin-10 production by ODN-activated human B cells,” Scandinavian Journal of Immunology, vol. 76, no. 4, pp. 371–377, 2012. View at Publisher · View at Google Scholar · View at Scopus