Impact of Kefir Derived Lactobacillus kefiri on the Mucosal Immune Response and Gut Microbiota

Table 2

Cytokine production after exposing PMBCs for 24 h to L. kefiri strains. Cytokines concentrations in culture cell supernatant (pg mL⁻¹) were measured using Flow Human Th1/Th2 11plex FlowCytomix Kit (eBioscience). The results are expressed as mean ± SD of experiments performed with three different donors.

L. kefiri	IL-1	IL-6	IL-8	IL-10	IFN-	TNF-	IL-12p70
CIDCA 8321	1294 ± 526	1552 ± 709	5771 ± 1284	205 ± 76	131 ± 22	10436 ± 3785	312 ± 72
CIDCA 8325	2050 ± 75	2571 ± 94	4824 ± 531	313 ± 11	59 ± 38	16169 ± 45	572 ± 94
CIDCA 8345	1655 ± 8	2033 ± 15	4399 ± 106	230 ± 3	85 ± 20	15368 ± 1075	449 ± 21
CIDCA 8348	1936 ± 10	2719 ± 13	3855 ± 40	435 ± 90	83 ± 4	13551 ± 198	502 ± 121
CIDCA 83115	1023 ± 60	1778 ± 12	3621 ± 34	192 ± 9	49 ± 2	8613 ± 500	738 ± 206
CIDCA 83111	604 ± 83	2401 ± 81	3806 ± 167	253 ± 1	103 ± 23	9908 ± 175	815 ± 189
CIDCA 83113	1148 ± 26	1722 ± 95	3920 ± 202	201 ± 11	53 ± 22	7514 ± 427	475 ± 59
JCM 5818	591 ± 103	919 ± 40	4228 ± 12	84 ± 2	62 ± 13	6872 ± 1647	246 ± 94
Nonstimulated PBMC	35 ± 2	71 ± 6	418 ± 202	21 ± 1	15 ± 11	175 ± 5	41 ± 13