Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome

Table 4

Parameter estimates from segregation analyses of early-onset families. For details in each model check Table 2. AD: autoimmune disease; PolyAD: polyautoimmunity; MAS: multiple autoimmune syndrome; ND: model not able to maximize.

Model/parameter									Sex		d.f.	value	AIC
AD
Random environmental	—	—	—	0.19	1.43				2.36	698.079	3	<0.05	708.079
Dominant	1.21		−109	0.05	0.00	1.00	0.50	0.00	2.16	707.994	5	<0.05	715.994
Dominant multifactorial	1.00		−1.16	0.07	−0.06	1.00	0.50	0.00	2.19	706.492	4	<0.05	716.492
Recessive	−1.09		1.21	0.95	0.00	1.00	0.50	0.00	2.16	707.994	5	<0.05	715.994
Recessive multifactorial	−1.15		1.33	0.94	−0.05	1.00	0.50	0.00	2.24	706.653	4	<0.05	716.653
Codominant	−33.00	1.41	−1.21	0.06	0.00	1.00	0.50	0.00	2.35	707.529	5	<0.05	717.529
Additive	1.94	0.38	−1.18	0.10	−0.09	1.00	0.50	0.00	2.08	706.956	5	<0.05	716.956
Mayor locus	−0.73	1.54	−2.07	0.01	0.00	0.56	0.00	1.00	2.14	667.079	1	0.52	679.079
General transmission	−0.75	1.49	−2.07	0.02	−0.05	0.56	0.00	1.00	2.13	666.871		Ref.	680.871
PolyAD
Random environmental	—	—	—	0.35	2.27				2.30	491.607	3	<0.05	501.607
Dominant	1.50		−2.09	0.01	0	1	0.5	0	2.10	499.629	5	<0.05	507.629
Dominant multifactorial	−0.89		−2.21	0.08	−0.22	1	0.5	0	1.89	499.127	4	<0.05	509.127
Recessive	−2.09		1.51	0.99	0	1	0.5	0	2.10	499.629	5	<0.05	507.629
Recessive multifactorial	−2.29		−0.98	0.90	−0.24	1	0.5	0	1.90	499.135	4	<0.05	509.135
Codominant	−48.15	1.44	−2.09	0.01	0	1	0.5	0	2.11	499.614	5	<0.05	509.614
Additive	−0.65	−1.56	−2.47	0.24	−0.27	1	0.5	0	1.85	499.233	5	<0.05	509.233
Mayor gene	−2.02	−0.44	−17.60	0.04	0	0.86	0.00	1.00	2.09	472.191	1	<0.05	484.191
General transmission	−66.10	−1.05	−3.47	0.00	1.86	1.00	0.00	0.39	1.86	459.356		Ref.	471.356
MAS
Random environmental	—	—	—	0.51	2.65				2.73	286.846	3	<0.05	296.846
Dominant	ND		ND	ND	0	1.00	0.50	0.00	ND	ND	5
Dominant multifactorial	−2.27		−4.32	0.25	−0.06	1.00	0.50	0.00	2.25	286.875	4	<0.05	296.875
Recessive	ND		ND	ND	0	1.00	0.50	0.00	ND	ND	5
Recessive multifactorial	−4.84		−2.28	0.72	−0.05	1.00	0.50	0.00	0.72	286.856	4	<0.05	296.856
Codominant	−2.27	−2.27	−4.66	0.27	0	1.00	0.50	0.00	−0.98	286.838	5	<0.05	298.838
Additive	−2.27	−4.14	−6.07	0.66	−0.97	1.00	0.50	0.00	2.25	287.122	5	<0.05	297.122
Mayor gene	24.70	−14.29	−18.36	0.00	0	0.00	0.00	0.15	37.20	271.525	1	<0.05	281.525
General transmission	−152.53	−3.36	−1.91	0.96	4.42	0.42	0.12	0.99	1.95	260.304		Ref.	276.304