Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome

Table 5

Parameter estimates from segregation analyses of early-onset families. AD: autoimmune disease. For details in each model check Table 2.

Model/parameter									Sex		d.f.	value	AIC
AD
Random environmental	—	—	—	0.01	−0.83				−0.02	426.292	3	0.55	438.292
Dominant	−1.05		−1.05	0.02	0	1	0.5	0	−0.03	451.220	5	<0.05	459.22
Dominant multifactorial	−1.99		−1.05	0.08	0.01	1	0.5	0	0.01	441.228	4	<0.05	451.228
Recessive	−1.07		−1.05	0.00	0	1	0.5	0	−0.03	451.220	5	<0.05	459.22
Recessive multifactorial	−2.80		−1.04	0.32	−0.53	1	0.5	0	0.01	440.46	4	<0.05	450.46
Codominant	−2.78	−1.05	−1.08	0.29	0	1	0.5	0	0.01	440.408	5	<0.05	452.408
Additive	−1.17	−1.17	−1.17	0.10	−0.48	1	0.5	0	0.01	441.265	5	<0.05	451.265
Mayor gene	115.3	21.2	−2.68	0.00	0	0.3	0.0	0.1	0.54	400.587	1	<0.05	412.587
General transmission	−9.57	−0.71	−0.91	0.32	−0.84	0.20	0.33	0.34	−0.005	427.342	0		443.342