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Journal of Immunology Research
Volume 2015 (2015), Article ID 679813, 9 pages
http://dx.doi.org/10.1155/2015/679813
Research Article

Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes

1Laboratório de Medicina Laboratorial (LIM03), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, Brazil
2Hospital Israelita Albert Einstein, 05652-900 São Paulo, SP, Brazil
3Instituto de Investigação em Imunologia, Instituto Nacional de Ciência e Tecnologia, 05403-000 São Paulo, SP, Brazil
4Laboratório de Imunologia, Instituto do Coração (InCor), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, Brazil
5Laboratório de Histocompatibilidade e Imunidade Celular (LIM19), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, Brazil
6Departamento de Hepatologia, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, Brazil
7Divisão de Alergia e Imunologia Clínica, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, SP, Brazil

Received 18 June 2015; Accepted 12 October 2015

Academic Editor: Fulvia Ceccarelli

Copyright © 2015 Léa Campos de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pediatric autoimmune hepatitis (AIH) patients present hypergammaglobulinemia, periportal CD8+ cytotoxic T cell infiltration, and cirrhosis. Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1. We previously detected increased IgE serum levels and sought to compare clinical and histological features according to IgE levels in AIH (, ages 1–14 years) patients. Additionally, we typed 117 patients and 227 controls for functional polymorphisms of IL4, IL13, IL5, and IL4RA genes involved in IgE switching and eosinophil maturation that might contribute to overall genetic susceptibility to AIH. Serum IgE levels were high in 55% of AIH-1, but only in 12% of AIH-2 () patients. Liver IgE was present in 91.3% of AIH-1 patients. The A alleles at both IL13 rs20541 and IL4RA rs1805011 were associated with AIH-1 (, OR = 1.55 and , OR = 2.15, resp.). Furthermore, individuals presenting homozygosis for the A allele at IL4RA rs1805011 and HLA-DRB1 and/or allele had sixfold greater risk to develop the disease (OR = 14.00, ). The novel association suggests an additional role for IgE-linked immune response genes in the pathogenesis of AIH.