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Journal of Immunology Research
Volume 2015, Article ID 724982, 8 pages
http://dx.doi.org/10.1155/2015/724982
Research Article

Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women

1Catholic University of Brasília, 71966-700 Brasília, DF, Brazil
2Federal University of Juiz de Fora, 36036-330 Governador Valadares, MG, Brazil
3University of Brasília, 70910-900 Brasília, DF, Brazil
4Paulista University, 70390-130 Brasília, DF, Brazil

Received 10 June 2015; Revised 28 August 2015; Accepted 10 September 2015

Academic Editor: Eileen Uribe-Querol

Copyright © 2015 João Bartholomeu-Neto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Failure in antimicrobial activity contributes to high morbidity and mortality in the geriatric population. Little is known about the potential effect of resistance training (RT) on the functional properties of the innate immunity. This study aimed to investigate the influence of long-term RT on the endocytic and oxidative activities of neutrophils and monocytes in healthy older women. Our results indicate that the phagocytosis index (PhI) of neutrophils (but not of monocytes) in the RT-adapted group was significantly higher (; effect size, () = 0.90, 95% CI: [0.75–1.04]) compared to that in sedentary subjects. In contrast, the oxidative activity of either neutrophils or monocytes was not significantly influenced by RT. Also, total energy and carbohydrate intake as well as serum IL6 levels had a significant influence on the phagocytic activity of neutrophils (), being considered in the model. Multivariate regression identified the physical condition of the subject (; ) as a significant predictor of PhI. In conclusion, circulating neutrophils of older women adapted to a long-term RT program expressed higher phagocytic activity.