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Journal of Immunology Research
Volume 2015, Article ID 794072, 11 pages
http://dx.doi.org/10.1155/2015/794072
Review Article

Neutrophil Leukocyte: Combustive Microbicidal Action and Chemiluminescence

Department of Pathology, Creighton University School of Medicine, Omaha, NE 68131, USA

Received 15 August 2015; Accepted 18 November 2015

Academic Editor: Carlos Rosales

Copyright © 2015 Robert C. Allen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. F. Bainton, “Developmental biology of neutrophils and eosinophils,” in Inflammation: Basic Principles and Clinical Correlates, J. I. Gallin and R. S. Snyderman, Eds., pp. 13–34, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 3rd edition, 1999. View at Google Scholar
  2. D. C. Dale, L. Boxer, and W. C. Liles, “The phagocytes: neutrophils and monocytes,” Blood, vol. 112, no. 4, pp. 935–945, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. R. C. Allen, P. R. Stevens, T. H. Price, G. S. Chatta, and D. C. Dale, “In vivo effects of recombinant human granulocyte colony-stimulating factor on neutrophil oxidative functions in normal human volunteers,” Journal of Infectious Diseases, vol. 175, no. 5, pp. 1184–1192, 1997. View at Publisher · View at Google Scholar · View at Scopus
  4. S. J. Klebanoff and R. A. Clark, The Neutrophil: Function and Clinical Disorders, North-Holland, New York, NY, USA, 1978.
  5. A. J. Sbarra and M. L. Karnovsky, “The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes,” The Journal of Biological Chemistry, vol. 234, no. 6, pp. 1355–1362, 1959. View at Google Scholar · View at Scopus
  6. C. C. Winterbourn and A. J. Kettle, “Redox reactions and microbial killing in the neutrophil phagosome,” Antioxidants and Redox Signaling, vol. 18, no. 6, pp. 642–660, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. R. C. Allen, R. L. Stjernholm, and R. H. Steele, “Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity,” Biochemical and Biophysical Research Communications, vol. 47, no. 4, pp. 679–684, 1972. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Rossi, D. Romeo, and P. Patriarca, “Mechanism of phagocytosis associated oxidative metabolism in polymorphonuclear leukocytes and macrophages,” Journal of the Reticuloendothelial Society, vol. 12, no. 2, pp. 127–149, 1972. View at Google Scholar · View at Scopus
  9. R. C. Allen, S. J. Yevich, R. W. Orth, and R. H. Steele, “The superoxide anion and singlet molecular oxygen: their role in the microbicidal activity of the polymorphonuclear leukocyte,” Biochemical and Biophysical Research Communications, vol. 60, no. 3, pp. 909–917, 1974. View at Publisher · View at Google Scholar · View at Scopus
  10. R. C. Allen, “Reduced, radical, and excited state oxygen in leukocyte microbicidal activity,” Frontiers of Biology, vol. 48, article 197, 1979. View at Google Scholar · View at Scopus
  11. D. Behar, G. Czapski, J. Rabani, L. M. Dorfman, and H. A. Schwarz, “The acid dissociation constant and decay kinetics of the perhydroxyl radical,” Journal of Physical Chemistry, vol. 74, no. 17, pp. 3209–3213, 1970. View at Publisher · View at Google Scholar · View at Scopus
  12. A. U. Khan, “Singlet molecular oxygen from superoxide anion and sensitized fluorescence of organic molecules,” Science, vol. 168, no. 3930, pp. 476–477, 1970. View at Publisher · View at Google Scholar · View at Scopus
  13. R. C. Allen, “Halide dependence of the myeloperoxidase-mediated antimicrobial system of the polymorphonuclear leukocyte in the phenomenon of electronic excitation,” Biochemical and Biophysical Research Communications, vol. 63, no. 3, pp. 675–683, 1975. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Kasha and A. Khan, “The physics, chemistry, and biology of singlet molecular oxygen,” Annals of the New York Academy of Sciences, vol. 171, pp. 1–33, 1970. View at Google Scholar
  15. L. Pauling, The Nature of the Chemical Bond, Cornell University Press, New York, NY, USA, 1960.
  16. R. C. Allen, “Role of oxygen in phagocyte microbicidal action,” Environmental Health Perspectives, vol. 102, no. 10, pp. 201–208, 1994. View at Publisher · View at Google Scholar · View at Scopus
  17. J. R. Waldram, The Theory of Thermodynamics, Cambridge University Press, Cambridge, UK, 1985.
  18. A. Sudbery, Quantum Mechanics and the Particles of Nature, Cambridge University Press, Cambridge, Cambridge, UK, 1986. View at MathSciNet
  19. P. A. M. Dirac, The Principles of Quantum Mechanics, Oxford, Oxford, UK, 4th edition, 1958. View at MathSciNet
  20. R. C. Allen, “Molecular oxygen (O2): reactivity and luminescence,” in Bioluminescence and Chemiluminescence. Progress & Current Applications, P. E. Stanley and L. J. Kricka, Eds., pp. 223–232, World Scientific, Cambridge, UK, 2002. View at Google Scholar
  21. K. Fukui, T. Yonezawa, and H. Shingu, “A molecular orbital theory of reactivity in aromatic hydrocarbons,” The Journal of Chemical Physics, vol. 20, no. 4, pp. 722–725, 1952. View at Publisher · View at Google Scholar · View at Scopus
  22. I. Fleming, Frontier Orbitals and Organic Chemical Reactions, John Wiley & Sons, Chichester, UK, 1978.
  23. M. Orchin and H. H. Jaffe, The Importance of Antibonding Orbitals, Houghton Mifflin, 1967.
  24. G. Herzberg, Molecular Spectra and Molecular Structure. Spectra of Diatomic Molecules, Van Nostrand Reinhold, New York, NY, USA, 1950.
  25. M. Hargittai and I. Hargittai, Symmetry through the Eyes of a Chemist, Springer, New York, NY, USA, 2010.
  26. J. Katriel and R. Pauncz, “Theoretical interpretation of Hund's rule,” Advances in Quantum Chemistry, vol. 10, pp. 143–185, 1977. View at Google Scholar
  27. E. Skovsen, J. W. Snyder, J. D. C. Lambert, and P. R. Ogilby, “Lifetime and diffusion of singlet oxygen in a cell,” The Journal of Physical Chemistry B, vol. 109, no. 18, pp. 8570–8573, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. R. W. Redmond and I. E. Kochevar, “Spatially resolved cellular responses to singlet oxygen,” Photochemistry and Photobiology, vol. 82, no. 5, pp. 1178–1186, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. N. J. Turro, V. Ramamurthy, and J. C. Scaiano, Principles of Molecular Photochemistry, University Science Books, Sausalito, Calif, USA, 2009.
  30. R. C. Allen, “Biochemiexcitation: chemiluminescence and the study of biological oxygenation,” in Chemical and Biological Generation of Excited States, pp. 310–344, Academic Press, New York, NY, USA, 1982. View at Google Scholar
  31. R. C. Allen, “Phagocytic leukocyte oxygenation activities and chemiluminescence: a kinetic approach to analysis,” Methods in Enzymology, vol. 133, pp. 449–493, 1986. View at Publisher · View at Google Scholar · View at Scopus
  32. D. L. Stevens, A. E. Bryant, J. Huffman, K. Thompson, and R. C. Allen, “Analysis of circulating phagocyte activity measured by whole blood luminescence: correlations with clinical status,” Journal of Infectious Diseases, vol. 170, no. 6, pp. 1463–1472, 1994. View at Publisher · View at Google Scholar · View at Scopus
  33. R. C. Allen and D. L. Stevens, “The circulating phagocyte reflects the in vivo state of immune defense,” Current Opinion in Infectious Diseases, vol. 5, no. 3, pp. 389–398, 1992. View at Publisher · View at Google Scholar · View at Scopus
  34. R. C. Allen, D. C. Dale, and F. B. Taylor Jr., “Blood phagocyte luminescence: gauging systemic immune activation,” Methods in Enzymology, vol. 305, pp. 591–629, 2000. View at Publisher · View at Google Scholar · View at Scopus
  35. F. Taylor Jr., P. A. Haddad, G. Kinasewitz, A. Chang, G. Peer, and R. C. Allen, “Luminescence studies of the phagocyte response to endotoxin infusion into normal human subjects: multiple discriminant analysis of luminescence response and correlation with phagocyte morphologic changes and release of elastase,” Journal of Endotoxin Research, vol. 6, no. 1, pp. 3–15, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. R. C. Allen, E. L. Mills, T. R. McNitt, and P. G. Quie, “Role of myeloperoxidase and bacterial metabolism in chemiluminescence of granulocytes from patients with chronic granulomatous disease,” Journal of Infectious Diseases, vol. 144, no. 4, pp. 344–348, 1981. View at Publisher · View at Google Scholar · View at Scopus
  37. E. L. Kaplan, T. Laxdal, and P. G. Quie, “Studies of polymorphonuclear leukocytes from patients with chronic granulomatous disease of childhood: bactericidal capacity for streptococci,” Pediatrics, vol. 41, no. 3, pp. 591–599, 1968. View at Google Scholar · View at Scopus
  38. W. H. Holzapfel, P. Haberer, R. Geisen, J. Björkroth, and U. Schillinger, “Taxonomy and important features of probiotic microorganisms in food and nutrition,” The American Journal of Clinical Nutrition, vol. 73, no. 2, pp. 365S–373S, 2001. View at Google Scholar · View at Scopus
  39. J. W. McLeod and J. Gordon, “Production of hydrogen peroxide by bacteria,” Biochemical Journal, vol. 16, pp. 499–504, 1922. View at Google Scholar
  40. J. Schultz and K. Kaminker, “Myeloperoxidase of the leucocyte of normal human blood. I. Content and localization,” Archives of Biochemistry and Biophysics, vol. 96, no. 3, pp. 465–467, 1962. View at Publisher · View at Google Scholar · View at Scopus
  41. D. G. Wright, A. I. Meierovics, and J. M. Foxley, “Assessing the delivery of neutrophils to tissues in neutropenia,” Blood, vol. 67, no. 4, pp. 1023–1030, 1986. View at Google Scholar · View at Scopus
  42. S. Cauci, S. Guaschino, D. De Aloysio et al., “Interrelationships of interleukin-8 with interleukin-1β and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women,” Molecular Human Reproduction, vol. 9, no. 1, pp. 53–58, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. R. C. Allen and J. T. Stephens Jr., “Reduced-oxidized difference spectral analysis and chemiluminescence-based Scatchard analysis demonstrate selective binding of myeloperoxidase to microbes,” Luminescence, vol. 26, no. 3, pp. 208–213, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. R. C. Allen and J. T. Stephens Jr., “Myeloperoxidase selectively binds and selectively kills microbes,” Infection and Immunity, vol. 79, no. 1, pp. 474–485, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. R. C. Allen and J. T. Stephens Jr., “Role of lactic acid bacteria-myeloperoxidase synergy in establishing and maintaining the normal flora in man,” Food and Nutrition Sciences, vol. 4, no. 11, pp. 67–72, 2013. View at Publisher · View at Google Scholar
  46. P. S. C. Matthews, Quantum Chemistry of Atoms and Molecules, Cambridge University Press, Cambridge, UK, 1986.