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Journal of Immunology Research
Volume 2015 (2015), Article ID 837859, 15 pages
http://dx.doi.org/10.1155/2015/837859
Research Article

Inhibins Tune the Thymocyte Selection Process by Regulating Thymic Stromal Cell Differentiation

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510 México, DF, Mexico

Received 26 September 2014; Revised 15 January 2015; Accepted 20 January 2015

Academic Editor: Oscar Bottasso

Copyright © 2015 Ebzadrel Carbajal-Franco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1. (A) The absolute cell numbers of TEC subpopulations from Inhα-/- and Inα+/+ mice showed a slight decrease in the numbers of cTECs and slight increase in mTECs, between Inhα-/- and Inhα+/+ mice. (B) MHCII expression showed a significant reduction within the cTEC MHCIIlo subpopulation from Inhα-/- mice compared to Inhα+/+ mice.

Supplementary Figure 2. The measurement of serum Activin A levels by ELISA showed increased levels of Activin A in all Inhα-/- mice compared to Inhα+/+ mice.

Supplementary Figure 3. The percentage of CD4SP thymocytes, but not the absolute cell numbers, show a significant reduction in Inhα-/- mice compared to Inhα+/+mice.

  1. Supplementary Material