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Journal of Immunology Research
Volume 2015 (2015), Article ID 902137, 8 pages
http://dx.doi.org/10.1155/2015/902137
Research Article

Serum CEACAM1 Elevation Correlates with Melanoma Progression and Failure to Respond to Adoptive Cell Transfer Immunotherapy

1The Ella Lemelbaum Institute for Melanoma, Sheba Medical Center, 52621 Tel Hashomer, Israel
2Talpiot Medical Leadership Program, Sheba Medical Center, 52621 Tel Hashomer, Israel
3Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, 69102 Tel Aviv, Israel

Received 16 July 2015; Revised 8 October 2015; Accepted 15 October 2015

Academic Editor: Roberta Castriconi

Copyright © 2015 R. Ortenberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Malignant melanoma is a devastating disease whose incidences are continuously rising. The recently approved antimelanoma therapies carry new hope for metastatic patients for the first time in decades. However, the clinical management of melanoma is severely hampered by the absence of effective screening tools. The expression of the CEACAM1 adhesion molecule on melanoma cells is a strong predictor of poor prognosis. Interestingly, a melanoma-secreted form of CEACAM1 (sCEACAM1) has recently emerged as a potential tumor biomarker. Here we add novel evidences supporting the prognostic role of serum CEACAM1 by using a mice xenograft model of human melanoma and showing a correlation between serum CEACAM1 and tumor burden. Moreover, we demonstrate that serum CEACAM1 is elevated over time in progressive melanoma patients who fail to respond to immunotherapy as opposed to responders and stable disease patients, thus proving a correlation between sCEACAM1, response to treatment, and clinical deterioration.