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Journal of Immunology Research
Volume 2016 (2016), Article ID 2349817, 11 pages
http://dx.doi.org/10.1155/2016/2349817
Review Article

Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase

1Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, VIC 3168, Australia
2Department of Nephrology, Monash Health, Clayton, VIC 3168, Australia

Received 11 October 2015; Accepted 21 December 2015

Academic Editor: Carlos Rosales

Copyright © 2016 Dragana Odobasic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.