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Journal of Immunology Research
Volume 2016 (2016), Article ID 2697860, 7 pages
http://dx.doi.org/10.1155/2016/2697860
Clinical Study

Patterns of Early Rejection in Renal Retransplantation: A Single-Center Experience

1Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
2Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China
3Key Laboratory of Organ Transplantation, Ministry of Public Health, Wuhan, China

Received 23 September 2016; Accepted 9 November 2016

Academic Editor: Junchao Cai

Copyright © 2016 Lan Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It has been reported that kidney retransplant patients had high rates of early acute rejection due to previous sensitization. In addition to the acute antibody-mediated rejection (ABMR) that has received widespread attention, the early acute T-cell-mediated rejection (TCMR) may be another important issue in renal retransplantation. In the current single-center retrospective study, we included 33 retransplant patients and 90 first transplant patients with similar protocols of induction and maintenance therapy. Analysis focused particularly on the incidence and patterns of early acute rejection episodes, as well as one-year graft and patient survival. Excellent short-term clinical outcomes were obtained in both groups, with one-year graft and patient survival rates of 93.9%/100% in the retransplant group and 92.2%/95.6% in the first transplant group. Impressively, with our strict immunological selection and desensitization criteria, the retransplant patients had a very low incidence of early acute ABMR (6.1%), which was similar to that in the first transplant patients (4.4%). However, a much higher rate of early acute TCMR was observed in the retransplant group than in the first transplant group (30.3% versus 5.6%, ). Acute TCMR that develops early after retransplantation should be monitored in order to obtain better transplant outcomes.