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Journal of Immunology Research
Volume 2017, Article ID 5134760, 12 pages
https://doi.org/10.1155/2017/5134760
Review Article

Metabolic Plasticity in Dendritic Cell Responses: Implications in Allergic Asthma

Department of Pathobiology, College of Veterinary Medicine, 254 Greene Hall, Auburn University, Auburn, AL 36849, USA

Correspondence should be addressed to Amarjit Mishra; ude.nrubua@arhsim.tijrama

Received 22 August 2017; Accepted 7 November 2017; Published 14 December 2017

Academic Editor: Abdallah Elkhal

Copyright © 2017 Amarjit Mishra. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dendritic cells (DCs) are highly specialized in antigen presentation and play a pivotal role in the initiation, progression, and perpetuation of adaptive immune responses. Emerging immune pathways are being recognized increasingly for DCs and their subsets that differentially regulate T lymphocyte function based on the type and interactions with the antigen. However, these interactions not only alter the signaling process and DC function but also render metabolic plasticity. The current review focuses on the metabolic cues of DCs that coordinate DC activation and differentiation and discuss whether targeting these fundamental cellular processes have implications to control airway inflammation and adaptive immunity. Therefore, strategies using metabolism-based therapeutic manipulation of DC functions could be developed into novel treatments for airway inflammation and asthma.