Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2017, Article ID 7680434, 8 pages
Research Article

Polymorphism rs2073618 of the TNFRSF11B (OPG) Gene and Bone Mineral Density in Mexican Women with Rheumatoid Arthritis

1Unidad Biomédica 02, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, JAL, Mexico
2Doctorado en Farmacología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (U. de G.), 44340 Guadalajara, JAL, Mexico
3División de Ciencias de la Salud, Departamento de Ciencias Biomédicas, Centro Universitario de Tonalá (CUTonalá), U. de G., 48525 Tonalá, JAL, Mexico
4Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, CUCS, U. de G., 44340 Guadalajara, JAL, Mexico
5UDG-CA-703, Grupo de Investigación en Inmunología y Reumatología, CUCS, U. de G., 44340 Guadalajara, JAL, Mexico
6Departamento de Biología Molecular y Genómica, CUCS, U. de G., 44340 Guadalajara, JAL, Mexico
7División de Investigación, UMAE, Hospital de Especialidades, CMNO, IMSS, 44349 Guadalajara, JAL, Mexico
8Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingeniería (CUCEI), U. de G., 44430 Guadalajara, JAL, Mexico
9Departamento de Epidemiología, Unidad Médica Familiar 4 y 8, IMSS, 44220 Guadalajara, JAL, Mexico
10Departamento de Salud Pública, CUCS, U. de G., 44340 Guadalajara, JAL, Mexico
11Departamento de Medicina Interna-Reumatología, Hospital General Regional 110, IMSS, 44710 Guadalajara, JAL, Mexico
12División de Ciencias de la salud, Departamento Salud-Enfermedad como Proceso Individual, CUTonalá, U. de G., 48525 Tonalá, JAL, Mexico
13UDG CA-701 Grupo de Investigación Inmunometabolismo en Enfermedades Emergentes (GIIEE), CUCS, U. de G., 44340 Guadalajara, JAL, Mexico
14Laboratorio de Investigación y Desarrollo Farmacéutico, CUCEI, U. de G., 44430 Guadalajara, JAL, Mexico
15Unidad Medica Familiar 97, IMSS, 46470 Magdalena, JAL, Mexico
16Programa de Doctorado en Ciencias Médicas, Universidad de Colima, 28040 Colima, COL, Mexico
17Departamento de Medicina Interna-Reumatología, Hospital General de Zona 45, IMSS, 44860 Guadalajara, JAL, Mexico

Correspondence should be addressed to J. I. Gamez-Nava; xm.ten.ygidorp@zemagnavird

Received 4 January 2017; Revised 6 May 2017; Accepted 18 May 2017; Published 5 July 2017

Academic Editor: Fulvia Ceccarelli

Copyright © 2017 C. A. Nava-Valdivia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Osteoporosis (OP) is highly prevalent in rheumatoid arthritis (RA) and is influenced by genetic factors. Single-nucleotide polymorphism (SNP) rs2073618 in the TNFRSF11B osteoprotegerin (OPG) gene has been related to postmenopausal OP although, to date, no information has been described concerning whether this polymorphism is implied in abnormalities of bone mineral density (BMD) in RA. We evaluated, in a case-control study performed in Mexican-Mestizo women with RA, whether SNP rs2073618 in the TNFRSF11B gene is associated with a decrease in BMD. RA patients were classified as follows: (1) low BMD and (2) normal BMD. All patients were genotyped for the rs2073618 polymorphism by PCR-RFLP. The frequency of low BMD was 74.4%. Higher age was observed in RA with low BMD versus normal BMD (62 and 54 years, resp.; ). Worse functioning and lower BMI were observed in RA with low BMD ( and , resp.). We found similar genotype frequencies in RA with low BMD versus RA with normal BMD (GG genotype 71% versus 64.4%, GC 26% versus 33%, and CC 3% versus 2.2%, resp.; ). We concluded that in Mexican-Mestizo female patients with RA, the rs2073618 polymorphism of the TNRFS11B gene is not associated with low BMD.