Journal of Immunology Research

Genetic Factors of Autoimmune Diseases 2017


Publishing date
26 May 2017
Status
Published
Submission deadline
06 Jan 2017

1Sapienza Università di Roma, Roma, Italy

2Tel Aviv University, Tel Aviv, Israel


Genetic Factors of Autoimmune Diseases 2017

Description

As widely demonstrated, autoimmune diseases are characterized by a multifactorial pathogenesis, in which genetic and environmental factors interact in determining disease development. Data identifying a higher concordance ratio between monozygotic twins compared to dizygotic twins or siblings have confirmed the role of genetic factors in patients affected by autoimmune diseases. To date, thanks to genomewide association studies, several genetic loci have been identified as associated with disease susceptibility. The identification of the same genetic modifications in different autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, suggests a shared immune pathogenesis. The genetic polymorphisms could influence not only the susceptibility, but also the disease phenotype, as demonstrated by the association of different loci with specific clinical manifestations or outcomes, such as response to treatment.

The proteins encoded by the genes associated with autoimmune diseases development are involved in several mechanisms participating to inflammatory process, such as antigen presentation, type I interferon, toll-like receptor and NF-κB signaling, B- and T-cell function, apoptosis, and clearance of cellular debris and immune complexes. The genetic polymorphisms could determine modifications of these proteins, in terms of production rate and function, with possible changes in the related processes.

To date, more than 200 genetic loci have been associated with one or more disorders. Further studies are needed to better understand the implications of these associations in the susceptibility and phenotype of autoimmune diseases.

We invite investigators to contribute with original research articles as well as review articles that will stimulate the continuing efforts to better understand the genetic factors involved in the autoimmune diseases.

Potential topics include but are not limited to the following:

  • Role of genetic factors in determining disease susceptibility
  • Role of genetic factors as markers of disease outcome in terms of chronic damage development and response to treatment

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 2789242
  • - Editorial

Genetic Factors of Autoimmune Diseases 2017

Fulvia Ceccarelli | Nancy Agmon-Levin | Carlo Perricone
  • Special Issue
  • - Volume 2017
  • - Article ID 7680434
  • - Research Article

Polymorphism rs2073618 of the TNFRSF11B (OPG) Gene and Bone Mineral Density in Mexican Women with Rheumatoid Arthritis

C. A. Nava-Valdivia | A. M. Saldaña-Cruz | ... | J. I. Gamez-Nava
  • Special Issue
  • - Volume 2017
  • - Article ID 5295164
  • - Review Article

Genetic Polymorphisms of Cytotoxic T-Lymphocyte Antigen 4 in Primary Biliary Cholangitis: A Meta-Analysis

Xing-Chen Yang | Masayuki Fujino | ... | Xiao-Kang Li
  • Special Issue
  • - Volume 2017
  • - Article ID 4758539
  • - Review Article

Genetics and Molecular Biology of Epstein-Barr Virus-Encoded BART MicroRNA: A Paradigm for Viral Modulation of Host Immune Response Genes and Genome Stability

David H. Dreyfus
  • Special Issue
  • - Volume 2017
  • - Article ID 2185083
  • - Research Article

Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study

Urszula Wasik | Ewa Wunsch | ... | Małgorzata Milkiewicz
  • Special Issue
  • - Volume 2017
  • - Article ID 3073504
  • - Review Article

Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis

Satoru Joshita | Takeji Umemura | ... | Masao Ota
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision91 days
Acceptance to publication32 days
CiteScore3.330
Impact Factor3.404
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