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Journal of Immunology Research
Volume 2017, Article ID 8596181, 6 pages
https://doi.org/10.1155/2017/8596181
Clinical Study

Impacts of Anti-dsDNA Antibody on In Vitro Fertilization-Embryo Transfer and Frozen-Thawed Embryo Transfer

Reproductive Medicine Center for The First Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Reproductive Medicine of Guangdong Province, Guangzhou 510080, China

Correspondence should be addressed to Yiping Zhong; moc.361@66rotcodpyz

Received 18 January 2017; Accepted 27 March 2017; Published 30 April 2017

Academic Editor: Jacek Tabarkiewicz

Copyright © 2017 Jiao Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. S. Kaider, B. D. Kaider, P. B. Janowicz, and R. G. Roussev, “Immunodiagnostic evaluation in women with reproductive failure,” American Journal of Reproductive Immunology, vol. 42, no. 6, pp. 335–346, 1999. View at Publisher · View at Google Scholar
  2. K. Kikuchi, H. Shibahara, Y. Hirano et al., “Antinuclear antibody reduces the pregnancy rate in the first IVF-ET treatment cycle but not the cumulative pregnancy rate without specific medication,” American Journal of Reproductive Immunology, vol. 50, no. 4, pp. 363–367, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. J. J. Dias, R. M. de Oliveira, and M. S. Abrao, “Antinuclear antibodies and endometriosis,” International Journal of Gynaecology and Obstetrics, vol. 93, no. 3, pp. 262–263, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Ticconi, F. Rotondi, M. Veglia et al., “Antinuclear autoantibodies in women with recurrent pregnancy loss,” American Journal of Reproductive Immunology, vol. 64, no. 6, pp. 384–392, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. B. H. Hahn, “Antibodies to DNA,” The New England Journal of Medicine, vol. 338, no. 19, pp. 1359–1368, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Deocharan, X. Qing, E. Beger, and C. Putterman, “Antigenic triggers and molecular targets for anti-double-stranded DNA antibodies,” Lupus, vol. 11, no. 12, pp. 865–871, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. R. H. Weisbart, M. Stempniak, S. Harris, D. J. Zack, and K. Ferreri, “An autoantibody is modified for use as a delivery system to target the cell nucleus: therapeutic implications,” Journal of Autoimmunity, vol. 11, no. 5, pp. 539–546, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Yanase and M. P. Madaio, “Nuclear localizing anti-DNA antibodies enter cells via caveoli and modulate expression of caveolin and p53,” Journal of Autoimmunity, vol. 24, no. 2, pp. 145–151, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Alarcon-Segovia, A. Ruiz-Arguelles, and E. Fishbein, “Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc receptors,” Nature, vol. 271, no. 5640, pp. 67–69, 1978. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Alarcon-Segovia, A. Ruiz-Arguelles, and L. Llorente, “Broken dogma: penetration of autoantibodies into living cells,” Immunology Today, vol. 17, no. 4, pp. 163–164, 1996. View at Google Scholar
  11. M. H. Foster, T. Kieber-Emmons, M. Ohliger, and M. P. Madaio, “Molecular and structural analysis of nuclear localizing anti-DNA lupus antibodies,” Immunologic Research, vol. 13, no. 2–3, pp. 186–206, 1994. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Reichlin, “Cellular dysfunction induced by penetration of autoantibodies into living cells: cellular damage and dysfunction mediated by antibodies to dsDNA and ribosomal P proteins,” Journal of Autoimmunity, vol. 11, no. 5, pp. 557–561, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. D. J. Zack, M. Stempniak, A. L. Wong, C. Taylor, and R. H. Weisbart, “Mechanisms of cellular penetration and nuclear localization of an anti-double strand DNA autoantibody,” Journal of Immunology, vol. 157, no. 5, pp. 2082–2088, 1996. View at Google Scholar
  14. M. R. Ehrenstein, D. R. Katz, M. H. Griffiths et al., “Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice,” Kidney International, vol. 48, no. 3, pp. 705–711, 1995. View at Publisher · View at Google Scholar
  15. C. L. Yu, M. H. Huang, C. Y. Tsai et al., “The effect of human polyclonal anti-dsDNA autoantibodies on apoptotic gene expression in cultured rat glomerular mesangial cells,” Scandinavian Journal of Rheumatology, vol. 27, no. 1, pp. 54–60, 1998. View at Google Scholar
  16. S. C. Hsieh, K. H. Sun, C. Y. Tsai et al., “Monoclonal anti-double stranded DNA antibody is a leucocyte-binding protein to up-regulate interleukin-8 gene expression and elicit apoptosis of normal human polymorphonuclear neutrophils,” Rheumatology (Oxford), vol. 40, no. 8, pp. 851–858, 2001. View at Publisher · View at Google Scholar
  17. T. Kubota, N. Watanabe, Y. Kanai, and B. D. Stollar, “Enhancement of oxidative cleavage of DNA by the binding sites of two anti-double-stranded DNA antibodies,” The Journal of Biological Chemistry, vol. 271, no. 11, pp. 6555–6561, 1996. View at Google Scholar
  18. E. Koren, M. Koscec, M. Wolfson-Reichlin et al., “Murine and human antibodies to native DNA that cross-react with the A and D SnRNP polypeptides cause direct injury of cultured kidney cells,” Journal of Immunology, vol. 154, no. 9, pp. 4857–4864, 1995. View at Google Scholar
  19. S. Schmidt-Acevedo, B. Perez-Romano, and A. Ruiz-Arguelles, “LE cells’ result from phagocytosis of apoptotic bodies induced by antinuclear antibodies,” Journal of Autoimmunity, vol. 15, no. 1, pp. 15–20, 2000. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Ying, Y. P. Zhong, C. Q. Zhou et al., “Antinuclear antibodies predicts a poor IVF-ET outcome: impaired egg and embryo development and reduced pregnancy rate,” Immunological Investigations, vol. 41, no. 5, pp. 458–468, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Ying, Y. P. Zhong, C. Q. Zhou et al., “A further exploration of the impact of antinuclear antibodies on in vitro fertilization-embryo transfer outcome,” American Journal of Reproductive Immunology, vol. 70, no. 3, pp. 221–229, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. K. H. Sun, C. L. Yu, S. J. Tang, and G. H. Sun, “Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha from normal human mononuclear cells involving in the lupus pathogenesis,” Immunology, vol. 99, no. 3, pp. 352–360, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. C. L. Yu, K. H. Sun, C. Y. Tsai, S. C. Hsieh, and H. S. Yu, “Anti-dsDNA antibody up-regulates interleukin 6, but not cyclo-oxygenase, gene expression in glomerular mesangial cells: a marker of immune-mediated renal damage?” Inflammation Research, vol. 50, no. 1, pp. 12–18, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. S. M. Delimitreva, R. S. Zhivkova, I. T. Vatev, and D. I. Toncheva, “Chromosomal disorders and nuclear and cell destruction in cleaving human embryos,” The International Journal of Developmental Biology, vol. 49, no. 4, pp. 409–416, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Levy, “Genetic regulation of preimplantation embryo survival,” International Review of Cytology, vol. 210, pp. 1–37, 2001. View at Google Scholar
  26. K. Hardy, S. Spanos, D. Becker, P. Iannelli, R. M. Winston, and J. Stark, “From cell death to embryo arrest: mathematical models of human preimplantation embryo development,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 4, pp. 1655–1660, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. G. I. Perez and J. L. Tilly, “Cumulus cells are required for the increased apoptotic potential in oocytes of aged mice,” Human Reproduction, vol. 12, no. 12, pp. 2781–2783, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Wu, L. Zhang, and X. Wang, “Maturation and apoptosis of human oocytes in vitro are age-related,” Fertility and Sterility, vol. 74, no. 6, pp. 1137–1141, 2000. View at Publisher · View at Google Scholar · View at Scopus