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Journal of Immunology Research
Volume 2018, Article ID 1436236, 8 pages
Research Article

Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias

1Department of Pulmonary Medicine, Allergy and Rheumatology, Iwate Medical University School of Medicine, Morioka, Japan
2Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
3Department of Cancer Biology, Iwate Medical University, Shiwa, Japan
4Division of Diagnostic Pathology, Itabashi Chuo Medical Center, Tokyo, Japan
5Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan
6Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan

Correspondence should be addressed to Masahiro Yamashita;

Received 26 October 2017; Accepted 14 December 2017; Published 4 February 2018

Academic Editor: Zissis Chroneos

Copyright © 2018 Masahiro Yamashita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The types of cells most significantly linked to individual subtypes of idiopathic interstitial pneumonias (IIPs) remain unclear. Few studies have examined CD163+ macrophages in IIPs. Objective. We retrospectively aimed to immunohistochemically characterize the CD163+ macrophages in IIPs. Methods. Paraffin-embedded lung tissue samples were obtained from 47 patients with IIPs, including idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (NSIP), and cryptogenic organizing pneumonia (COP), and 12 normal controls were immunohistochemically analyzed, using primary antibodies against CD68 and CD163 as indicators of pan and M2 macrophages, respectively. Results. CD68+ macrophage density was significantly increased in the 3 subtypes of IIPs relative to that in the control group, although no difference was detected within the different IIPs. CD163+ macrophage density was significantly increased in NSIP and COP samples relative to that in IPF samples. The density ratio of CD163+ macrophages to CD68+ macrophages was significantly decreased in IPF/UIP samples relative to that in the others, while the densities in NSIP and COP were significantly higher than those in control cases. Conclusion. CD163+ macrophages show distinct profiles among IIPs, and the standardized numerical density is decreased in IPF cases that have poor prognoses.