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Journal of Immunology Research
Volume 2018, Article ID 2361963, 6 pages
Review Article

The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection

1Department of Clinical Laboratory, Translational Medicine Center, Huaihe Hospital Affiliated to Henan University, Kaifeng, Henan 475000, China
2Department of Nephrology, First Affiliated Hospital of Henan University, Kaifeng, Henan 475000, China

Correspondence should be addressed to Xuhong Lin; nc.ude.ijgnot@hxl627008

Received 5 January 2018; Revised 15 May 2018; Accepted 29 May 2018; Published 25 July 2018

Academic Editor: Lucia Conti

Copyright © 2018 Ruilin Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatitis B can cause acute or chronic liver damage due to hepatitis B virus (HBV) infection. Cirrhosis or hepatocellular carcinoma (HCC) caused by chronic HBV infection often leads to increased mortality. However, the gut and liver have the same embryonic origin; therefore, a close relationship must exist in terms of anatomy and function, and the gut microbiota plays an important role in host metabolic and immune modulation. It is believed that structural changes in the gut microbiota, bacterial translocation, and the resulting immune injury may affect the occurrence and development of liver inflammation caused by chronic HBV infection based on the in-depth cognition of the concept of the “gut-liver axis” and the progress in intestinal microecology. This review aims to summarize and discuss the immunologic role of the gut microbiota in chronic HBV infection.