March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

Figure 7

The OVA challenge of immunized mice is associated with an increase in the number of lung CD88^Interm. alveolar macrophages and CD88-positive lymphocytes relative to sham-sensitized groups in the two strains, the magnitude of which is reduced in the absence of March1. CD88-expressing lung lymphocytes were identified by flow cytometry (a). Alveolar macrophages were identified as in Figure 1(a). The numbers of CD88^Hi and CD88^Interm alveolar macrophages were expressed as absolute numbers (b). Absolute numbers of CD88-positive T cells and B lymphocytes are shown in (c). denotes statistically significant, (trend). Data are pooled from 3 independent experiments and presented as mean with SEM; –8/group.

(a)

(b)

(c)