The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response

Figure 2

Schematic of macrophage-mediated inflammatory response through PLC signaling. PLCβ1-2, PLCγ1-2, and PLCδ shown in black indicated that these PLC isoforms are expressed in macrophages and are involved in macrophage-mediated inflammatory response. PLCβ3 and PLCδ3 shown in blue indicated that their involvement in inflammatory response has been identified in epithelial cell but not in macrophages. PLCβ4, PLCδ4, PLCζ, and PLCη1-2 shown in red indicated that whether they are involved in inflammatory response has not been identified. PLCε shown in green indicated that the involvement of inflammatory response has been identified with mouse model, in vivo. But whether it regulates inflammatory response in macrophages has not been identified.