Myeloperoxidase and Eosinophil Peroxidase Inhibit Endotoxin Activity and Increase Mouse Survival in a Lipopolysaccharide Lethal Dose 90% Model

Figure 2

Percent inhibition of Limulus amebocyte lysate (LAL) endotoxin activity for 0.1 ng lipopolysaccharide (LPS)/well plotted against mg/well of myeloperoxidase (MPO), shown as filled circles, eosinophil peroxidase (EPO), shown as open circles, or glucose oxidase (GO), shown as open triangles (at 0 baseline; no gradient). The regression equations plus ² values are shown for MPO and for EPO. The % inhibition of 0.1 ng LPS is proportional to the natural log of the MPO or EPO mass. GO produced no inhibition. Additional statistical information is described in Table 1.